Synthesis of a mixed carboxylate-phosphinate AAZTA-like ligand and relaxometric characterization of its GdIII complex

Angelo Ermelindo; Giuseppe Gambino; Lorenzo Tei

doi:10.1016/j.tetlet.2013.09.070

Synthesis of a mixed carboxylate-phosphinate AAZTA-like ligand and relaxometric characterization of its Gd^III complex

Angelo Ermelindo, Giuseppe Gambino, Lorenzo Tei

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The synthesis of the new polydentate ligand AAZ2A2P^Et derived from the heptadentate polyaminocarboxylic ligand AAZTA (6-amino-6- methylperhydro-1,4-diazepine-N,N′,N″,N″-tetraacetic acid) in which two acetate groups were replaced by methyleneethylphosphinic pendant arms is reported. The relaxometric behavior of the corresponding mono-aquo Gd ^III complex was also investigated.

Lingua originale	Inglese
pagine (da-a)	6378-6380
Numero di pagine	3
Rivista	Tetrahedron Letters
Volume	54
Numero di pubblicazione	47
DOI	https://doi.org/10.1016/j.tetlet.2013.09.070
Stato di pubblicazione	Pubblicato - 20 nov 2013

Accesso al documento

10.1016/j.tetlet.2013.09.070

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{77cd81d59ee941ce97fcdf5db389ba71,

title = "Synthesis of a mixed carboxylate-phosphinate AAZTA-like ligand and relaxometric characterization of its GdIII complex",

abstract = "The synthesis of the new polydentate ligand AAZ2A2PEt derived from the heptadentate polyaminocarboxylic ligand AAZTA (6-amino-6- methylperhydro-1,4-diazepine-N,N′,N″,N″-tetraacetic acid) in which two acetate groups were replaced by methyleneethylphosphinic pendant arms is reported. The relaxometric behavior of the corresponding mono-aquo Gd III complex was also investigated.",

keywords = "Contrast agent, Gadolinium, Magnetic Resonance Imaging, Phosphinates, Relaxivity",

author = "Angelo Ermelindo and Giuseppe Gambino and Lorenzo Tei",

year = "2013",

month = nov,

day = "20",

doi = "10.1016/j.tetlet.2013.09.070",

language = "English",

volume = "54",

pages = "6378--6380",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "47",

}

TY - JOUR

T1 - Synthesis of a mixed carboxylate-phosphinate AAZTA-like ligand and relaxometric characterization of its GdIII complex

AU - Ermelindo, Angelo

AU - Gambino, Giuseppe

AU - Tei, Lorenzo

PY - 2013/11/20

Y1 - 2013/11/20

N2 - The synthesis of the new polydentate ligand AAZ2A2PEt derived from the heptadentate polyaminocarboxylic ligand AAZTA (6-amino-6- methylperhydro-1,4-diazepine-N,N′,N″,N″-tetraacetic acid) in which two acetate groups were replaced by methyleneethylphosphinic pendant arms is reported. The relaxometric behavior of the corresponding mono-aquo Gd III complex was also investigated.

AB - The synthesis of the new polydentate ligand AAZ2A2PEt derived from the heptadentate polyaminocarboxylic ligand AAZTA (6-amino-6- methylperhydro-1,4-diazepine-N,N′,N″,N″-tetraacetic acid) in which two acetate groups were replaced by methyleneethylphosphinic pendant arms is reported. The relaxometric behavior of the corresponding mono-aquo Gd III complex was also investigated.

KW - Contrast agent

KW - Gadolinium

KW - Magnetic Resonance Imaging

KW - Phosphinates

KW - Relaxivity

UR - https://www.scopus.com/pages/publications/84885909634

U2 - 10.1016/j.tetlet.2013.09.070

DO - 10.1016/j.tetlet.2013.09.070

M3 - Article

SN - 0040-4039

VL - 54

SP - 6378

EP - 6380

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 47