Synthesis of a fluorescent sulfatide for the study of CD1 antigen binding properties

Laura Franchini, Federica Compostella, Alena Donda, Lucia Mori, Diego Colombo, Gennaro De Libero, Pamela Matto, Fiamma Ronchetti, Luigi Panza

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A fluorescent derivative of sulfatide, labeled with a dansyl probe at position 6 of galactose, was prepared through a glycosylation reaction between a 6-O-functionalized galactose donor and 3-O-benzoyl-azidosphingosine. The sphingoid acceptor was obtained in high yield through exploitation of a highly stereoselective nucleophilic addition of pentadecyne to 2,3-O-cyclohexylidene-D- glyceraldehyde. The fluorescent sulfatide binds to soluble recombinant human CD1a and is a valuable tool for the study of CD1 antigen binding properties.

Lingua originaleInglese
pagine (da-a)4755-4761
Numero di pagine7
RivistaEuropean Journal of Organic Chemistry
Numero di pubblicazione23
DOI
Stato di pubblicazionePubblicato - 26 nov 2004

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