@article{32bb4dbc420d4de9864b55118a8b1c1d,
title = "Synthesis and evaluation of human T cell stimulating activity of an α-sulfatide analogue",
abstract = "A concise synthesis of α-sulfatide 1, an analogue of natural glycolipid antigens with potential anti-tumor activity, was performed. Two different approaches to the α-glycosidic bond were explored, resulting in a high yield and excellent stereoselectivity. Compound 1 combines the structural features of sulfated β-GalCer (sulfatide) and α-GalCer, which activate specific T cells. α-Sulfatide 1 was stimulatory for CD1d-restricted semi-invariant Natural Killer T (iNKT) cell clones, although less potent than α-GalCer, while it was not recognized by CD1a-restricted sulfatide-specific T cells.",
keywords = "Galactosylceramides, Glycosylation, Immunostimulation, NKT cell activation",
author = "Laura Franchini and Pamela Matto and Fiamma Ronchetti and Luigi Panza and Lucia Barbieri and Valeria Costantino and Alfonso Mangoni and Marco Cavallari and Lucia Mori and {De Libero}, Gennaro",
note = "Funding Information: This work was supported by MIUR-Italy, COFIN 2004: “Structure and synthesis of glycolipids” (to F.R. and A.M.), the Swiss National Foundation Grant 3100A0-109918 (to G.D.L.), the MOLSTROKE project, Contract No. LSH-CT-2004-005206, funded under the EU FP6-2003 LIFESCIHEALTH programme (to G.D.L.), and the Swiss Society of Multiple Sclerosis, the University of Piemonte Orientale and IRCAD-Novara (to L.P.).",
year = "2007",
month = aug,
day = "15",
doi = "10.1016/j.bmc.2007.05.044",
language = "English",
volume = "15",
pages = "5529--5536",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ltd.",
number = "16",
}