Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids

Giovanni Appendino; Andrea Bertolino; Alberto Minassi; Rita Annunziata; Arpad Szallasi; Luciano De Petrocellis; Vincenzo Di Marzo

doi:10.1002/ejoc.200400122

Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids

Giovanni Appendino, Andrea Bertolino, Alberto Minassi, Rita Annunziata, Arpad Szallasi, Luciano De Petrocellis, Vincenzo Di Marzo

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Phorboid 20-homovanillates modified on ring C to mimic the constitution and conformation of the ultrapotent vanilloid resiniferatoxin (RTX) and on the AB ring system to suppress the tumour-promoting potential of the terpenoid core were prepared. Several unexpected reactions were discovered, and the structure-activity relationships for this class of vanilloid ligands were expanded.

Lingua originale	Inglese
pagine (da-a)	3413-3421
Numero di pagine	9
Rivista	European Journal of Organic Chemistry
Numero di pubblicazione	16
DOI	https://doi.org/10.1002/ejoc.200400122
Stato di pubblicazione	Pubblicato - 13 ago 2004

Accesso al documento

10.1002/ejoc.200400122

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{44880c3a674c4fdda3974e6a8b00f8f0,

title = "Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids",

abstract = "Phorboid 20-homovanillates modified on ring C to mimic the constitution and conformation of the ultrapotent vanilloid resiniferatoxin (RTX) and on the AB ring system to suppress the tumour-promoting potential of the terpenoid core were prepared. Several unexpected reactions were discovered, and the structure-activity relationships for this class of vanilloid ligands were expanded.",

keywords = "Natural products, Phorbol, Resiniferatoxin, Terpenoids, Vanilloids",

author = "Giovanni Appendino and Andrea Bertolino and Alberto Minassi and Rita Annunziata and Arpad Szallasi and {De Petrocellis}, Luciano and {Di Marzo}, Vincenzo",

year = "2004",

month = aug,

day = "13",

doi = "10.1002/ejoc.200400122",

language = "English",

pages = "3413--3421",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley-VCH Verlag",

number = "16",

}

TY - JOUR

T1 - Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids

AU - Appendino, Giovanni

AU - Bertolino, Andrea

AU - Minassi, Alberto

AU - Annunziata, Rita

AU - Szallasi, Arpad

AU - De Petrocellis, Luciano

AU - Di Marzo, Vincenzo

PY - 2004/8/13

Y1 - 2004/8/13

N2 - Phorboid 20-homovanillates modified on ring C to mimic the constitution and conformation of the ultrapotent vanilloid resiniferatoxin (RTX) and on the AB ring system to suppress the tumour-promoting potential of the terpenoid core were prepared. Several unexpected reactions were discovered, and the structure-activity relationships for this class of vanilloid ligands were expanded.

AB - Phorboid 20-homovanillates modified on ring C to mimic the constitution and conformation of the ultrapotent vanilloid resiniferatoxin (RTX) and on the AB ring system to suppress the tumour-promoting potential of the terpenoid core were prepared. Several unexpected reactions were discovered, and the structure-activity relationships for this class of vanilloid ligands were expanded.

KW - Natural products

KW - Phorbol

KW - Resiniferatoxin

KW - Terpenoids

KW - Vanilloids

UR - http://www.scopus.com/inward/record.url?scp=4544338171&partnerID=8YFLogxK

U2 - 10.1002/ejoc.200400122

DO - 10.1002/ejoc.200400122

M3 - Article

SN - 1434-193X

SP - 3413

EP - 3421

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 16

ER -

Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo