Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

Luciano Barboni; Roberto Ballini; Guido Giarlo; Giovanni Appendino; Gabriele Fontana; Ezio Bombardelli

doi:10.1016/j.bmcl.2005.08.066

Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

Luciano Barboni, Roberto Ballini, Guido Giarlo, Giovanni Appendino, Gabriele Fontana, Ezio Bombardelli

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m- methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.

Lingua originale	Inglese
pagine (da-a)	5182-5186
Numero di pagine	5
Rivista	Bioorganic and Medicinal Chemistry Letters
Volume	15
Numero di pubblicazione	23
DOI	https://doi.org/10.1016/j.bmcl.2005.08.066
Stato di pubblicazione	Pubblicato - 1 dic 2005
Pubblicato esternamente	Sì

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10.1016/j.bmcl.2005.08.066

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title = "Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390",

abstract = "Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m- methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.",

keywords = "IDN5109, IDN5390, Methoxylated, Newer generation taxoids, Paclitaxel",

author = "Luciano Barboni and Roberto Ballini and Guido Giarlo and Giovanni Appendino and Gabriele Fontana and Ezio Bombardelli",

year = "2005",

month = dec,

day = "1",

doi = "10.1016/j.bmcl.2005.08.066",

language = "English",

volume = "15",

pages = "5182--5186",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

AU - Barboni, Luciano

AU - Ballini, Roberto

AU - Giarlo, Guido

AU - Appendino, Giovanni

AU - Fontana, Gabriele

AU - Bombardelli, Ezio

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m- methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.

AB - Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m- methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.

KW - IDN5109

KW - IDN5390

KW - Methoxylated

KW - Newer generation taxoids

KW - Paclitaxel

UR - https://www.scopus.com/pages/publications/26844487304

U2 - 10.1016/j.bmcl.2005.08.066

DO - 10.1016/j.bmcl.2005.08.066

M3 - Article

SN - 0960-894X

VL - 15

SP - 5182

EP - 5186

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

Abstract

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