Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390

Luciano Barboni, Roberto Ballini, Guido Giarlo, Giovanni Appendino, Gabriele Fontana, Ezio Bombardelli

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m- methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.

Lingua originaleInglese
pagine (da-a)5182-5186
Numero di pagine5
RivistaBioorganic and Medicinal Chemistry Letters
Volume15
Numero di pubblicazione23
DOI
Stato di pubblicazionePubblicato - 1 dic 2005
Pubblicato esternamente

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