Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

Luisella Verotta; Giovanni Appendino; Emanuela Belloro; Federica Bianchi; Olov Sterner; Marco Lovati; Ezio Bombardelli

doi:10.1021/np0105681

Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

Luisella Verotta
, Giovanni Appendino
, Emanuela Belloro
, Federica Bianchi
, Olov Sterner
, Marco Lovati
, Ezio Bombardelli

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.

Lingua originale	Inglese
pagine (da-a)	433-438
Numero di pagine	6
Rivista	Journal of Natural Products
Volume	65
Numero di pubblicazione	4
DOI	https://doi.org/10.1021/np0105681
Stato di pubblicazione	Pubblicato - 2002
Pubblicato esternamente	Sì

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10.1021/np0105681

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title = "Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety",

abstract = "Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.",

author = "Luisella Verotta and Giovanni Appendino and Emanuela Belloro and Federica Bianchi and Olov Sterner and Marco Lovati and Ezio Bombardelli",

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T1 - Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

AU - Verotta, Luisella

AU - Appendino, Giovanni

AU - Belloro, Emanuela

AU - Bianchi, Federica

AU - Sterner, Olov

AU - Lovati, Marco

AU - Bombardelli, Ezio

PY - 2002

Y1 - 2002

N2 - Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.

AB - Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.

UR - https://www.scopus.com/pages/publications/0036235522

U2 - 10.1021/np0105681

DO - 10.1021/np0105681

M3 - Article

SN - 0163-3864

VL - 65

SP - 433

EP - 438

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

Abstract

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