Synthesis and antimalarial activities of some furoxan sulfones and related furazans

Ubaldina Galli; Loretta Lazzarato; Massimo Bertinaria; Giovanni Sorba; Alberto Gasco; Silvia Parapini; Donatella Taramelli

doi:10.1016/j.ejmech.2005.05.001

Synthesis and antimalarial activities of some furoxan sulfones and related furazans

Ubaldina Galli, Loretta Lazzarato, Massimo Bertinaria, Giovanni Sorba, Alberto Gasco, Silvia Parapini, Donatella Taramelli

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine- sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the -SO₂R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.

Lingua originale	Inglese
pagine (da-a)	1335-1340
Numero di pagine	6
Rivista	European Journal of Medicinal Chemistry
Volume	40
Numero di pubblicazione	12
DOI	https://doi.org/10.1016/j.ejmech.2005.05.001
Stato di pubblicazione	Pubblicato - dic 2005

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10.1016/j.ejmech.2005.05.001

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title = "Synthesis and antimalarial activities of some furoxan sulfones and related furazans",

abstract = "Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine- sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the -SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.",

keywords = "Antimalarial, Furoxanyl sulfones, Nitric oxide, Plasmodium falciparum",

author = "Ubaldina Galli and Loretta Lazzarato and Massimo Bertinaria and Giovanni Sorba and Alberto Gasco and Silvia Parapini and Donatella Taramelli",

note = "Funding Information: This work was supported by the grants from Turin University to A.G. and the Italian Minister of the University and Research, PRIN 2003-062554004 to D.T.",

year = "2005",

month = dec,

doi = "10.1016/j.ejmech.2005.05.001",

language = "English",

volume = "40",

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T1 - Synthesis and antimalarial activities of some furoxan sulfones and related furazans

AU - Galli, Ubaldina

AU - Lazzarato, Loretta

AU - Bertinaria, Massimo

AU - Sorba, Giovanni

AU - Gasco, Alberto

AU - Parapini, Silvia

AU - Taramelli, Donatella

N1 - Funding Information: This work was supported by the grants from Turin University to A.G. and the Italian Minister of the University and Research, PRIN 2003-062554004 to D.T.

PY - 2005/12

Y1 - 2005/12

N2 - Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine- sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the -SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.

AB - Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine- sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the -SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.

KW - Antimalarial

KW - Furoxanyl sulfones

KW - Nitric oxide

KW - Plasmodium falciparum

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U2 - 10.1016/j.ejmech.2005.05.001

DO - 10.1016/j.ejmech.2005.05.001

M3 - Article

SN - 0223-5234

VL - 40

SP - 1335

EP - 1340

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 12

ER -

Synthesis and antimalarial activities of some furoxan sulfones and related furazans

Abstract

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