Switching the N-Capping Region from all-L to all-D Amino Acids in a VEGF Mimetic Helical Peptide

Lucia De Rosa, Donatella Diana, Domenica Capasso, Rachele STEFANIA, Rossella Di Stasi, Roberto Fattorusso, Luca Domenico D'Andrea

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The N-capping region of an alpha-helix is a short N-terminal amino acid stretch that contributes to nucleate and stabilize the helical structure. In the VEGF mimetic helical peptide QK, the N-capping region was previously demonstrated to be a key factor of QK helical folding. In this paper, we explored the effect of the chiral inversion of the N-capping sequence on QK folding, performing conformational analysis in solution by circular dichroism and NMR spectroscopy. The effect of such a modification on QK stability in serum and the proliferative effect were also evaluated.
Lingua originaleInglese
RivistaMolecules
Volume27
Numero di pubblicazione20
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • D-amino acid
  • N-capping
  • NMR
  • peptide conformation
  • peptide folding
  • α-helix

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