Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

Andrea Pession; Elisa Dama; Roberto Rondelli; Corrado Magnani; Marisa De Rosa; Franco Locatelli; Franca Fagioli; Riccardo Haupt; Momcilo Jankovic; Benedetto Terracini; Franco Merletti; Guido Pastore

doi:10.1016/j.ejca.2008.03.020

Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

Andrea Pession, Elisa Dama, Roberto Rondelli, Corrado Magnani, Marisa De Rosa, Franco Locatelli, Franca Fagioli, Riccardo Haupt, Momcilo Jankovic, Benedetto Terracini, Franco Merletti, Guido Pastore

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.

Lingua originale	Inglese
pagine (da-a)	1282-1289
Numero di pagine	8
Rivista	European Journal of Cancer
Volume	44
Numero di pubblicazione	9
DOI	https://doi.org/10.1016/j.ejca.2008.03.020
Stato di pubblicazione	Pubblicato - giu 2008
Pubblicato esternamente	Sì

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10.1016/j.ejca.2008.03.020

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Pession, A., Dama, E., Rondelli, R., Magnani, C., De Rosa, M., Locatelli, F., Fagioli, F., Haupt, R., Jankovic, M., Terracini, B., Merletti, F., & Pastore, G. (2008). Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP). European Journal of Cancer, 44(9), 1282-1289. https://doi.org/10.1016/j.ejca.2008.03.020

@article{fbd93d6db295447a9a181b309729c855,

title = "Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)",

abstract = "We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.",

keywords = "Cancer registration, Childhood cancer, Gender, Italy, Survival",

author = "Andrea Pession and Elisa Dama and Roberto Rondelli and Corrado Magnani and {De Rosa}, Marisa and Franco Locatelli and Franca Fagioli and Riccardo Haupt and Momcilo Jankovic and Benedetto Terracini and Franco Merletti and Guido Pastore",

note = "Funding Information: This study was partially supported by the Italian Association for Cancer Research and Compagnia San Paolo/FIRMS. The funding association had no role in the design of this study, the data collection, the analysis and interpretation of the results, or the writing of the manuscript. The authors thank Ms. Assunta Rasulo and Lucia Nonnato for the careful conduct of the follow-up. ",

year = "2008",

month = jun,

doi = "10.1016/j.ejca.2008.03.020",

language = "English",

volume = "44",

pages = "1282--1289",

journal = "European Journal of Cancer",

issn = "0959-8049",

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Pession, A, Dama, E, Rondelli, R, Magnani, C, De Rosa, M, Locatelli, F, Fagioli, F, Haupt, R, Jankovic, M, Terracini, B, Merletti, F & Pastore, G 2008, 'Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)', European Journal of Cancer, vol. 44, n. 9, pagg. 1282-1289. https://doi.org/10.1016/j.ejca.2008.03.020

Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP). / Pession, Andrea; Dama, Elisa; Rondelli, Roberto et al.
In: European Journal of Cancer, Vol. 44, N. 9, 06.2008, pag. 1282-1289.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

AU - Pession, Andrea

AU - Dama, Elisa

AU - Rondelli, Roberto

AU - Magnani, Corrado

AU - De Rosa, Marisa

AU - Locatelli, Franco

AU - Fagioli, Franca

AU - Haupt, Riccardo

AU - Jankovic, Momcilo

AU - Terracini, Benedetto

AU - Merletti, Franco

AU - Pastore, Guido

N1 - Funding Information: This study was partially supported by the Italian Association for Cancer Research and Compagnia San Paolo/FIRMS. The funding association had no role in the design of this study, the data collection, the analysis and interpretation of the results, or the writing of the manuscript. The authors thank Ms. Assunta Rasulo and Lucia Nonnato for the careful conduct of the follow-up.

PY - 2008/6

Y1 - 2008/6

N2 - We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.

AB - We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.

KW - Cancer registration

KW - Childhood cancer

KW - Gender

KW - Italy

KW - Survival

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DO - 10.1016/j.ejca.2008.03.020

M3 - Article

SN - 0959-8049

VL - 44

SP - 1282

EP - 1289

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 9

ER -

Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

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