TY - JOUR
T1 - Sulpiride effects on nigral and striatal glutamic acid decarboxylase activity
T2 - A possible involvement of prolactin
AU - Nicoletti, Ferdinando
AU - Canonico, Pier Luigi
AU - Patti, Francesco
AU - Rampello, Liborio
AU - Condorelli, Daniele Filippo
AU - Giammona, Giovanni
AU - Di Giorgio, Rosa Maria
AU - Scapagnini, Umberto
PY - 1982/1/22
Y1 - 1982/1/22
N2 - Sulpiride, a benzamide derivative neuroleptic, was shown to significantly increase glutamic acid decarboxylase activity in substantia nigra and corpus striatum in either acutely or chronically injected male rats. Hypophysectomy completely prevented this effect suggesting an involvement of an anterior pituitary factor in the central action of sulpiride. Prolactin might possibly mediate the effects of sulpiride since it is known to increase prolactin secretion by an action at the level of the anterior pituitary. Consistent with this hypothesis was the finding of a similar increase in nigral and striatal glutamic acid decarboxylase activity in hyperprolactinemic animals in which an anterior pituitary had been implanted under the kidney capsule.
AB - Sulpiride, a benzamide derivative neuroleptic, was shown to significantly increase glutamic acid decarboxylase activity in substantia nigra and corpus striatum in either acutely or chronically injected male rats. Hypophysectomy completely prevented this effect suggesting an involvement of an anterior pituitary factor in the central action of sulpiride. Prolactin might possibly mediate the effects of sulpiride since it is known to increase prolactin secretion by an action at the level of the anterior pituitary. Consistent with this hypothesis was the finding of a similar increase in nigral and striatal glutamic acid decarboxylase activity in hyperprolactinemic animals in which an anterior pituitary had been implanted under the kidney capsule.
KW - Corpus striatum
KW - Glutamic acid decarboxylase activity
KW - Prolactin
KW - Substantia nigra
KW - Sulpiride
UR - https://www.scopus.com/pages/publications/0020043821
U2 - 10.1016/0014-2999(82)90007-3
DO - 10.1016/0014-2999(82)90007-3
M3 - Article
SN - 0014-2999
VL - 77
SP - 131
EP - 135
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -