TY - JOUR
T1 - Successful Simultaneous Pancreas Kidney Transplantation from Living-Related Donor Against Positive Cross-Match
AU - Sammartino, Cinzia
AU - Pham, Thuy
AU - Panaro, Fabrizio
AU - Bogetti, Diego
AU - Jarzembowski, Tomasz
AU - Sankary, Howard
AU - Morelli, Nicola
AU - Testa, Giuliano
AU - Benedetti, Enrico
PY - 2004/1
Y1 - 2004/1
N2 - A positive pretransplant flow cytometry cross-match (FC-XM) allows precise identification of high-risk recipients vulnerable to hyperacute or accelerated rejection after transplantation. Living donor kidney transplant recipient candidates with positive cross-match have been successfully treated with a combination of plasmapheresis (therapeutic plasma exchange, TPEX) and intravenous immunoglobulin (IVIG), achieving conversion to negative cross-match and successful transplant. We report the first successful case of simultaneous pancreas kidney transplant (SPKT) from a living donor (LD) performed against an initially positive FC-XM, converted to negative using a protocol based on TPEX and IVIG in combination with antiCD20 monoclonal antibody. This strategy of overcoming the cross-match barriers in living donation may offer a chance of successful transplantation to highly sensitized candidates for SPKT, for whom cadaveric transplant is difficult to achieve.
AB - A positive pretransplant flow cytometry cross-match (FC-XM) allows precise identification of high-risk recipients vulnerable to hyperacute or accelerated rejection after transplantation. Living donor kidney transplant recipient candidates with positive cross-match have been successfully treated with a combination of plasmapheresis (therapeutic plasma exchange, TPEX) and intravenous immunoglobulin (IVIG), achieving conversion to negative cross-match and successful transplant. We report the first successful case of simultaneous pancreas kidney transplant (SPKT) from a living donor (LD) performed against an initially positive FC-XM, converted to negative using a protocol based on TPEX and IVIG in combination with antiCD20 monoclonal antibody. This strategy of overcoming the cross-match barriers in living donation may offer a chance of successful transplantation to highly sensitized candidates for SPKT, for whom cadaveric transplant is difficult to achieve.
KW - Crossmatch
KW - Plasma exchange
KW - Simultaneous kidney-pancreas transplant
UR - https://www.scopus.com/pages/publications/0742266703
U2 - 10.1046/j.1600-6135.2003.00296.x
DO - 10.1046/j.1600-6135.2003.00296.x
M3 - Article
SN - 1600-6135
VL - 4
SP - 140
EP - 143
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 1
ER -