Study on the photostability of octyl-p-methoxy cinnamate in SLN

M. Eugenia Carlotti; S. Sapino; D. Vione; E. Pelizzetti; E. Ugazio; S. Morel

doi:10.1081/DIS-200063141

Study on the photostability of octyl-p-methoxy cinnamate in SLN

M. Eugenia Carlotti, S. Sapino, D. Vione, E. Pelizzetti, E. Ugazio, S. Morel

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The aim of this study was to prepare solid lipid nanoparticles (SLNs) of octyl-p-methoxycinnamate (OMC) to improve the photostability of this UV adsorber. It was found that the rate of photodegradation is significantly dependent upon the initial concentration of the active substance and could be halved in SLN form. When different concentration of nonionic surfactant solutions were compared, it was found that OMC photodegraded more quickly from a medium containing fewer surfactant micelles. Photodegradation rate of OMC was investigated spectrophotometrically while nanoparticles were characterized by particle size examination, zeta potential determination, and thermal analysis.

Lingua originale	Inglese
pagine (da-a)	809-816
Numero di pagine	8
Rivista	Journal of Dispersion Science and Technology
Volume	26
Numero di pubblicazione	6
DOI	https://doi.org/10.1081/DIS-200063141
Stato di pubblicazione	Pubblicato - 2005

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abstract = "The aim of this study was to prepare solid lipid nanoparticles (SLNs) of octyl-p-methoxycinnamate (OMC) to improve the photostability of this UV adsorber. It was found that the rate of photodegradation is significantly dependent upon the initial concentration of the active substance and could be halved in SLN form. When different concentration of nonionic surfactant solutions were compared, it was found that OMC photodegraded more quickly from a medium containing fewer surfactant micelles. Photodegradation rate of OMC was investigated spectrophotometrically while nanoparticles were characterized by particle size examination, zeta potential determination, and thermal analysis.",

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AU - Carlotti, M. Eugenia

AU - Sapino, S.

AU - Vione, D.

AU - Pelizzetti, E.

AU - Ugazio, E.

AU - Morel, S.

PY - 2005

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N2 - The aim of this study was to prepare solid lipid nanoparticles (SLNs) of octyl-p-methoxycinnamate (OMC) to improve the photostability of this UV adsorber. It was found that the rate of photodegradation is significantly dependent upon the initial concentration of the active substance and could be halved in SLN form. When different concentration of nonionic surfactant solutions were compared, it was found that OMC photodegraded more quickly from a medium containing fewer surfactant micelles. Photodegradation rate of OMC was investigated spectrophotometrically while nanoparticles were characterized by particle size examination, zeta potential determination, and thermal analysis.

AB - The aim of this study was to prepare solid lipid nanoparticles (SLNs) of octyl-p-methoxycinnamate (OMC) to improve the photostability of this UV adsorber. It was found that the rate of photodegradation is significantly dependent upon the initial concentration of the active substance and could be halved in SLN form. When different concentration of nonionic surfactant solutions were compared, it was found that OMC photodegraded more quickly from a medium containing fewer surfactant micelles. Photodegradation rate of OMC was investigated spectrophotometrically while nanoparticles were characterized by particle size examination, zeta potential determination, and thermal analysis.

KW - Nonionic surfactant

KW - Photo protection

KW - Solid lipid nanoparticles (SLNs)

KW - Sunscreen

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DO - 10.1081/DIS-200063141

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EP - 816

JO - Journal of Dispersion Science and Technology

JF - Journal of Dispersion Science and Technology

IS - 6

ER -

Study on the photostability of octyl-p-methoxy cinnamate in SLN

Abstract

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