Studies on fatty liver with isolated hepatocytes. III. Cumene hydroperoxide-induced change of several cell functions

Elena Chiarpotto, Giuseppe Poli, Emanuele Albano, Enrico Gravela, Mario U. Dianzani

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Isolated rat hepatocytes have been treated with cumene hydroperoxide at concentrations not inducing irreversible cell damage. Under these experimental conditions cells show an enhanced lipid peroxidation, a decrease of glucose-6-phosphatase activity and of cytochrome P-450 content, and a stimulation of aminopyrene demethylation. Furthermore, the hepatocyte incorporation of amino acids is slightly but significantly reduced by the tested compound. Finally, because of the inhibitory effect of cumene hydroperoxide on cell lipoprotein but not on protein secretion, a mechanism of damage acting at the level of the assembly and maturation of lipoprotein micelles is postulated.

Lingua originaleInglese
pagine (da-a)191-201
Numero di pagine11
RivistaExperimental and Molecular Pathology
Volume41
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - ott 1984
Pubblicato esternamente

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