Studies on fatty liver with isolated hepatocytes. II. The action of carbon tetrachloride on lipid peroxidation, protein, and triglyceride synthesis and secretion

Giuseppe Poli, Enrico Gravela, Emanuele Albano, Mario U. Dianzani

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

This report describes some effects of poisoning with carbon tetrachloride on hepatocytes in single cell suspension. In isolated liver cells as well as "in vivo" CCl4 stimulates lipid peroxidation, inhibits both protein synthesis and protein and lipoprotein secretion and induces fat accumulation within the cells. As the action of CCl4 on lipid peroxidation, our data confirm that its increase induced by CCl4 depends on the metabolism of this drug by the NADPH-cytochrome P450 enzyme system. Furthermore, data reported here suggest that the onset of the CCl4-induced decrease of lipoprotein secretion is due to a derangement of the secretory pathway.

Lingua originaleInglese
pagine (da-a)116-127
Numero di pagine12
RivistaExperimental and Molecular Pathology
Volume30
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - feb 1979
Pubblicato esternamente

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