Abstract
This report describes some effects of poisoning with carbon tetrachloride on hepatocytes in single cell suspension. In isolated liver cells as well as "in vivo" CCl4 stimulates lipid peroxidation, inhibits both protein synthesis and protein and lipoprotein secretion and induces fat accumulation within the cells. As the action of CCl4 on lipid peroxidation, our data confirm that its increase induced by CCl4 depends on the metabolism of this drug by the NADPH-cytochrome P450 enzyme system. Furthermore, data reported here suggest that the onset of the CCl4-induced decrease of lipoprotein secretion is due to a derangement of the secretory pathway.
Lingua originale | Inglese |
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pagine (da-a) | 116-127 |
Numero di pagine | 12 |
Rivista | Experimental and Molecular Pathology |
Volume | 30 |
Numero di pubblicazione | 1 |
DOI | |
Stato di pubblicazione | Pubblicato - feb 1979 |
Pubblicato esternamente | Sì |