Structure of a complex of two plasma proteins: Transthyretin and retinol-binding protein

Hugo L. Monaco, Menico Rizzi, Alessandro Coda

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms. One tetramer of transthyretin was bound to two molecules of retinol-binding protein. The two retinol-binding protein molecules established molecular interactions with the same transthyretin dimer, and each also made contacts with one of the other two monomers. Thus, the other two potential binding sites in a transthyretin tetramer were blocked. The amino acid residues of the retinol-binding protein that were involved in the contacts were close to the retinol-binding site.

Lingua originaleInglese
pagine (da-a)1039-1041
Numero di pagine3
RivistaScience
Volume268
Numero di pubblicazione5213
DOI
Stato di pubblicazionePubblicato - 1995
Pubblicato esternamente

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