Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

S. Aime; A. S. Batsanov; M. Botta; J. A.K. Howard; M. P. Lowe; D. Parker

doi:10.1039/a901704f

Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

S. Aime
, A. S. Batsanov
, M. Botta
, J. A.K. Howard
, M. P. Lowe
, D. Parker

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Octadentate N₅O₃ ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd-N(py) bond [2.535(1) Å], and the water exchange rate (k(ox)/²⁹⁸ = 2.7 x 10⁶ s^-1) is sufficiently fast so as not to limit the pH independent relaxivity (R(1p)/²⁹⁸ = 5.3 mM^-1 s^-1, 20 MHz).

Lingua originale	Inglese
pagine (da-a)	669-670
Numero di pagine	2
Rivista	New Journal of Chemistry
Volume	23
Numero di pubblicazione	7
DOI	https://doi.org/10.1039/a901704f
Stato di pubblicazione	Pubblicato - 1999
Pubblicato esternamente	Sì

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10.1039/a901704f

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title = "Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents",

abstract = "Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd-N(py) bond [2.535(1) {\AA}], and the water exchange rate (k(ox)/298 = 2.7 x 106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R(1p)/298 = 5.3 mM-1 s-1, 20 MHz).",

author = "S. Aime and Batsanov, \{A. S.\} and M. Botta and Howard, \{J. A.K.\} and Lowe, \{M. P.\} and D. Parker",

year = "1999",

doi = "10.1039/a901704f",

language = "English",

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journal = "New Journal of Chemistry",

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T1 - Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

AU - Aime, S.

AU - Batsanov, A. S.

AU - Botta, M.

AU - Howard, J. A.K.

AU - Lowe, M. P.

AU - Parker, D.

PY - 1999

Y1 - 1999

N2 - Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd-N(py) bond [2.535(1) Å], and the water exchange rate (k(ox)/298 = 2.7 x 106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R(1p)/298 = 5.3 mM-1 s-1, 20 MHz).

AB - Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd-N(py) bond [2.535(1) Å], and the water exchange rate (k(ox)/298 = 2.7 x 106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R(1p)/298 = 5.3 mM-1 s-1, 20 MHz).

UR - https://www.scopus.com/pages/publications/0032798407

U2 - 10.1039/a901704f

DO - 10.1039/a901704f

M3 - Article

SN - 1144-0546

VL - 23

SP - 669

EP - 670

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 7

ER -

Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

Abstract

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