Structural and functional features of eukaryotic mRNA untranslated regions

Graziano Pesole; Flavio Mignone; Carmela Gissi; Giorgio Grillo; Flavio Licciulli; Sabino Liuni

doi:10.1016/S0378-1119(01)00674-6

Structural and functional features of eukaryotic mRNA untranslated regions

Graziano Pesole
, Flavio Mignone
, Carmela Gissi
, Giorgio Grillo
, Flavio Licciulli
, Sabino Liuni

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localization, stability and translation efficiency. We review in this paper the major structural and compositional features of eukaryotic mRNA untranslated regions and provide some examples of bioinformatic analyses for their functional characterization.

Lingua originale	Inglese
pagine (da-a)	73-81
Numero di pagine	9
Rivista	Gene
Volume	276
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/S0378-1119(01)00674-6
Stato di pubblicazione	Pubblicato - 3 ott 2001
Pubblicato esternamente	Sì

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10.1016/S0378-1119(01)00674-6

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title = "Structural and functional features of eukaryotic mRNA untranslated regions",

abstract = "The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localization, stability and translation efficiency. We review in this paper the major structural and compositional features of eukaryotic mRNA untranslated regions and provide some examples of bioinformatic analyses for their functional characterization.",

keywords = "Base composition, Bioinformatics, Biological database, Pattern recognition, Post-transcriptional regulation, Repeat elements, mRNA untranslated regions",

author = "Graziano Pesole and Flavio Mignone and Carmela Gissi and Giorgio Grillo and Flavio Licciulli and Sabino Liuni",

note = "Funding Information: This work has been supported by Ministero dell'Universit{\`a} e della Ricerca Scientifica e Tecnologica, Italy (projects: {\textquoteleft}Bioinformatics and Genomic Research{\textquoteright} (PRIN99), {\textquoteleft}Studio di geni di interesse biomedico e agroalimentare{\textquoteright} (Legge 488/92), {\textquoteleft}Biotecnologie{\textquoteright} (Legge 95/95, MURST 5\%)).",

year = "2001",

month = oct,

day = "3",

doi = "10.1016/S0378-1119(01)00674-6",

language = "English",

volume = "276",

pages = "73--81",

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T1 - Structural and functional features of eukaryotic mRNA untranslated regions

AU - Pesole, Graziano

AU - Mignone, Flavio

AU - Gissi, Carmela

AU - Grillo, Giorgio

AU - Licciulli, Flavio

AU - Liuni, Sabino

N1 - Funding Information: This work has been supported by Ministero dell'Università e della Ricerca Scientifica e Tecnologica, Italy (projects: ‘Bioinformatics and Genomic Research’ (PRIN99), ‘Studio di geni di interesse biomedico e agroalimentare’ (Legge 488/92), ‘Biotecnologie’ (Legge 95/95, MURST 5%)).

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Y1 - 2001/10/3

N2 - The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localization, stability and translation efficiency. We review in this paper the major structural and compositional features of eukaryotic mRNA untranslated regions and provide some examples of bioinformatic analyses for their functional characterization.

AB - The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localization, stability and translation efficiency. We review in this paper the major structural and compositional features of eukaryotic mRNA untranslated regions and provide some examples of bioinformatic analyses for their functional characterization.

KW - Base composition

KW - Bioinformatics

KW - Biological database

KW - Pattern recognition

KW - Post-transcriptional regulation

KW - Repeat elements

KW - mRNA untranslated regions

UR - https://www.scopus.com/pages/publications/0035802386

U2 - 10.1016/S0378-1119(01)00674-6

DO - 10.1016/S0378-1119(01)00674-6

M3 - Article

SN - 0378-1119

VL - 276

SP - 73

EP - 81

JO - Gene

JF - Gene

IS - 1-2

ER -

Structural and functional features of eukaryotic mRNA untranslated regions

Abstract

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