Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

RICCARDO MOIA; Micol Giulia Cittone; Paola Boggione; Giulia Francesca Manfredi; Chiara Favini; Bassel Awikeh; Anita Rebecca Pedrinelli; Abdurraouf Mokhtar Mahmoud; Maura Nicolosi; Mattia BELLAN; Pier Paolo SAINAGHI; Mario PIRISI; Gianluca GAIDANO; Andrea Patriarca; Cristina RIGAMONTI

doi:10.3389/fonc.2021.777730

Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

RICCARDO MOIA
, Micol Giulia Cittone
, Paola Boggione
, Giulia Francesca Manfredi
, Chiara Favini
, Bassel Awikeh
, Anita Rebecca Pedrinelli
, Abdurraouf Mokhtar Mahmoud
, Maura Nicolosi
, Mattia BELLAN
, Pier Paolo SAINAGHI
, Mario PIRISI
, Gianluca GAIDANO
, Andrea Patriarca
, Cristina RIGAMONTI

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells ≥10,000/ml (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.

Lingua originale	Inglese
pagine (da-a)	777730
Rivista	Frontiers in Oncology
Volume	11
DOI	https://doi.org/10.3389/fonc.2021.777730
Stato di pubblicazione	Pubblicato - 2021

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10.3389/fonc.2021.777730

http://hdl.handle.net/11579/130352

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MOIA, RICCARDO., Cittone, M. G., Boggione, P., Manfredi, G. F., Favini, C., Awikeh, B., Pedrinelli, A. R., Mahmoud, A. M., Nicolosi, M., BELLAN, M., SAINAGHI, P. P., PIRISI, M., GAIDANO, G., Patriarca, A., & RIGAMONTI, C. (2021). Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms. Frontiers in Oncology, 11, 777730. https://doi.org/10.3389/fonc.2021.777730

@article{f5ff33768eaf4bef95b0e5c861d54fac,

title = "Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms",

abstract = "A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells ≥10,000/ml (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.",

author = "RICCARDO MOIA and Cittone, \{Micol Giulia\} and Paola Boggione and Manfredi, \{Giulia Francesca\} and Chiara Favini and Bassel Awikeh and Pedrinelli, \{Anita Rebecca\} and Mahmoud, \{Abdurraouf Mokhtar\} and Maura Nicolosi and Mattia BELLAN and SAINAGHI, \{Pier Paolo\} and Mario PIRISI and Gianluca GAIDANO and Andrea Patriarca and Cristina RIGAMONTI",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 Moia, Cittone, Boggione, Manfredi, Favini, Awikeh, Pedrinelli, Mahmoud, Nicolosi, Bellan, Sainaghi, Pirisi, Gaidano, Patriarca and Rigamonti.",

year = "2021",

doi = "10.3389/fonc.2021.777730",

language = "English",

volume = "11",

pages = "777730",

journal = "Frontiers in Oncology",

issn = "2234-943X",

publisher = "Frontiers Media SA",

}

MOIA, RICCARDO, Cittone, MG, Boggione, P, Manfredi, GF, Favini, C, Awikeh, B, Pedrinelli, AR, Mahmoud, AM, Nicolosi, M, BELLAN, M , SAINAGHI, PP , PIRISI, M , GAIDANO, G, Patriarca, A & RIGAMONTI, C 2021, 'Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms', Frontiers in Oncology, vol. 11, pagg. 777730. https://doi.org/10.3389/fonc.2021.777730

TY - JOUR

T1 - Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

AU - MOIA, RICCARDO

AU - Cittone, Micol Giulia

AU - Boggione, Paola

AU - Manfredi, Giulia Francesca

AU - Favini, Chiara

AU - Awikeh, Bassel

AU - Pedrinelli, Anita Rebecca

AU - Mahmoud, Abdurraouf Mokhtar

AU - Nicolosi, Maura

AU - BELLAN, Mattia

AU - SAINAGHI, Pier Paolo

AU - PIRISI, Mario

AU - GAIDANO, Gianluca

AU - Patriarca, Andrea

AU - RIGAMONTI, Cristina

PY - 2021

Y1 - 2021

N2 - A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells ≥10,000/ml (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.

AB - A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells ≥10,000/ml (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.

UR - https://iris.uniupo.it/handle/11579/130352

U2 - 10.3389/fonc.2021.777730

DO - 10.3389/fonc.2021.777730

M3 - Article

SN - 2234-943X

VL - 11

SP - 777730

JO - Frontiers in Oncology

JF - Frontiers in Oncology

ER -

Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

Abstract

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