TY - JOUR
T1 - Spot-light on microbiota in obesity and cancer
AU - on behalf of the Obesity Programs of nutrition, Education, Research and Assessment (OPERA) group
AU - Marzullo, Paolo
AU - Bettini, Silvia
AU - Menafra, Davide
AU - Aprano, Sara
AU - Muscogiuri, Giovanna
AU - Barrea, Luigi
AU - Savastano, Silvia
AU - Colao, Annamaria
AU - Colao, Annamaria
AU - Savastano, Silvia
AU - Magno, Silvia
AU - Di Nisio, Andrea
AU - Romano, Fiammetta
AU - Muscogiuri, Giovanna
AU - Poggiogalle, Eleonora
AU - Venneri, Mary
AU - Liccardi, Alessia
AU - Tarsitano, Maria Grazia
AU - Barrea, Luigi
AU - Di Renzo, Laura
AU - Tuccinardi, Dario
AU - Caprio, Massimiliano
AU - Guzzardi, Maria Angela
AU - Pelosini, Caterina
AU - Pugliese, Gabriella
AU - Bottiglieri, Filomena
AU - Aprano, Sara
AU - Menafra, Davide
AU - Capellari, Gianluca Gortan
AU - Laudisio, Daniela
AU - Pivari, Francesca
AU - Brasacchio, Caterina
AU - Lenzi, Andrea
AU - Muratori, Fabrizio
AU - Santini, Ferruccio
AU - Busetto, Luca
AU - Sbraccia, Paolo
AU - Soldati, Laura
AU - Salvatore, Domenico
AU - Di Somma, Carolina
AU - Giugliano, Dario
AU - Gnessi, Lucio
AU - Capaldo, Brunella
AU - Riccardi, Gabriele
AU - Barazzoni, Rocco
AU - Guida, Brunella
AU - Bifulco, Maurizio
AU - Esposito, Katherine
AU - Vettor, Roberto
AU - Macchia, Paolo Emidio
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2021/11
Y1 - 2021/11
N2 - Over the last few years, the complexity and diversity of gut microbiota within and across individuals has been detailed in relation to human health. Further, understanding of the bidirectional association between gut microbiota and metabolic disorders has highlighted a complimentary, yet crucial role for microbiota in the onset and progression of obesity-related cancers. While strategies for cancer prevention and cure are known to work efficiently when supported by healthy diet and lifestyle choices and physical activity, emerging evidence suggests that the complex interplay relating microbiota both to neoplastic and metabolic diseases could aid strategies for cancer treatment and outcomes. This review will explore the experimental and clinical grounds supporting the functional role of gut microbiota in the pathophysiology and progression of cancers in relation to obesity and its metabolic correlates. Therapeutic approaches aiding microbiota restoration in connection with cancer treatments will be discussed.
AB - Over the last few years, the complexity and diversity of gut microbiota within and across individuals has been detailed in relation to human health. Further, understanding of the bidirectional association between gut microbiota and metabolic disorders has highlighted a complimentary, yet crucial role for microbiota in the onset and progression of obesity-related cancers. While strategies for cancer prevention and cure are known to work efficiently when supported by healthy diet and lifestyle choices and physical activity, emerging evidence suggests that the complex interplay relating microbiota both to neoplastic and metabolic diseases could aid strategies for cancer treatment and outcomes. This review will explore the experimental and clinical grounds supporting the functional role of gut microbiota in the pathophysiology and progression of cancers in relation to obesity and its metabolic correlates. Therapeutic approaches aiding microbiota restoration in connection with cancer treatments will be discussed.
UR - http://www.scopus.com/inward/record.url?scp=85117894688&partnerID=8YFLogxK
U2 - 10.1038/s41366-021-00866-7
DO - 10.1038/s41366-021-00866-7
M3 - Review article
SN - 0307-0565
VL - 45
SP - 2291
EP - 2299
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 11
ER -
