Sperm deliver a new second messenger: NAADP

Grant C. Churchill, John S. O'Neill, Roser Masgrau, Sandip Patel, Justyn M. Thomas, Armando A. Genazzani, Antony Galione

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

NAADP is a highly potent mobilizer of Ca2+ [1,2], which in turn triggers Ca2+-induced Ca2+ release pathways [3-6] in a wide range of species [2, 7]. Nevertheless, NAADP is not presently classified as a second messenger because it has not been shown to increase in response to a physiological stimulus. We now report a dramatic increase in NAADP during sea urchin egg fertilization that was largely due to production in sperm upon contacting egg jelly. The NAADP bolus plays a physiological role upon delivery to the egg based on its ability to induce a cortical flash, a depolarization-induced activation of L-type Ca2+ channels. Moreover, the sperm-induced cortical flash was eliminated in eggs desensitized to NAADP. We conclude that an NAADP increase plays a physiologically relevant role during fertilization and provides the first conclusive demonstration that NAADP is a genuine second messenger.

Lingua originaleInglese
pagine (da-a)125-128
Numero di pagine4
RivistaCurrent Biology
Volume13
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 21 gen 2003
Pubblicato esternamente

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