Specifically designed polymeric nanospheres increase cellular uptake of unmodified antisense ODNs

Luisa Tondelli; Michele Laus; Alfredo Ricca; Gennaro Citro

doi:10.1080/07328319908044820

Specifically designed polymeric nanospheres increase cellular uptake of unmodified antisense ODNs

Luisa Tondelli, Michele Laus, Alfredo Ricca, Gennaro Citro

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The cellular uptake and the inhibitory effect of c-myb unmodified antisense oligonucleotides reversibly bound to new polymeric nanoparticles in HL-60 cellular system have been found to increase by 50 folds if compared with the free ODN. An initial single dose (320 nM) of the nanoparticle bound unmodified antimyb ODN has been able to specifically inhibit HL-60 leukemia cell proliferation for at least 8 days.

Lingua originale	Inglese
pagine (da-a)	1677-1679
Numero di pagine	3
Rivista	Nucleosides and Nucleotides
Volume	18
Numero di pubblicazione	6-7
DOI	https://doi.org/10.1080/07328319908044820
Stato di pubblicazione	Pubblicato - 1999
Pubblicato esternamente	Sì

Accesso al documento

10.1080/07328319908044820

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{2415105b69df455fa3910eb657c40f63,

title = "Specifically designed polymeric nanospheres increase cellular uptake of unmodified antisense ODNs",

abstract = "The cellular uptake and the inhibitory effect of c-myb unmodified antisense oligonucleotides reversibly bound to new polymeric nanoparticles in HL-60 cellular system have been found to increase by 50 folds if compared with the free ODN. An initial single dose (320 nM) of the nanoparticle bound unmodified antimyb ODN has been able to specifically inhibit HL-60 leukemia cell proliferation for at least 8 days.",

author = "Luisa Tondelli and Michele Laus and Alfredo Ricca and Gennaro Citro",

year = "1999",

doi = "10.1080/07328319908044820",

language = "English",

volume = "18",

pages = "1677--1679",

journal = "Nucleosides and Nucleotides",

issn = "0732-8311",

publisher = "Marcel Dekker Inc.",

number = "6-7",

}

TY - JOUR

T1 - Specifically designed polymeric nanospheres increase cellular uptake of unmodified antisense ODNs

AU - Tondelli, Luisa

AU - Laus, Michele

AU - Ricca, Alfredo

AU - Citro, Gennaro

PY - 1999

Y1 - 1999

N2 - The cellular uptake and the inhibitory effect of c-myb unmodified antisense oligonucleotides reversibly bound to new polymeric nanoparticles in HL-60 cellular system have been found to increase by 50 folds if compared with the free ODN. An initial single dose (320 nM) of the nanoparticle bound unmodified antimyb ODN has been able to specifically inhibit HL-60 leukemia cell proliferation for at least 8 days.

AB - The cellular uptake and the inhibitory effect of c-myb unmodified antisense oligonucleotides reversibly bound to new polymeric nanoparticles in HL-60 cellular system have been found to increase by 50 folds if compared with the free ODN. An initial single dose (320 nM) of the nanoparticle bound unmodified antimyb ODN has been able to specifically inhibit HL-60 leukemia cell proliferation for at least 8 days.

UR - https://www.scopus.com/pages/publications/0032773623

U2 - 10.1080/07328319908044820

DO - 10.1080/07328319908044820

M3 - Article

SN - 0732-8311

VL - 18

SP - 1677

EP - 1679

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 6-7

ER -

Specifically designed polymeric nanospheres increase cellular uptake of unmodified antisense ODNs

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo