Solvatomorphism of moxidectin

Toni Grell; Mauro Barbero; Franco Pattarino; Giovanni Battista Giovenzana; Valentina Colombo

doi:10.3390/molecules26164869

Solvatomorphism of moxidectin

Toni Grell
, Mauro Barbero
, Franco Pattarino
, Giovanni Battista Giovenzana
, Valentina Colombo

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.

Lingua originale	Inglese
Numero di articolo	4869
Rivista	Molecules
Volume	26
Numero di pubblicazione	16
DOI	https://doi.org/10.3390/molecules26164869
Stato di pubblicazione	Pubblicato - 2 ago 2021

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10.3390/molecules26164869

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title = "Solvatomorphism of moxidectin",

abstract = "The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.",

keywords = "Moxidectin, Solvatomorphism, Variable-temperature PXRD, X-ray diffraction",

author = "Toni Grell and Mauro Barbero and Franco Pattarino and Giovenzana, \{Giovanni Battista\} and Valentina Colombo",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/molecules26164869",

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AU - Grell, Toni

AU - Barbero, Mauro

AU - Pattarino, Franco

AU - Giovenzana, Giovanni Battista

AU - Colombo, Valentina

PY - 2021/8/2

Y1 - 2021/8/2

N2 - The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.

AB - The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.

KW - Moxidectin

KW - Solvatomorphism

KW - Variable-temperature PXRD

KW - X-ray diffraction

UR - https://www.scopus.com/pages/publications/85112707067

U2 - 10.3390/molecules26164869

DO - 10.3390/molecules26164869

M3 - Article

SN - 1420-3049

VL - 26

JO - Molecules

JF - Molecules

IS - 16

M1 - 4869

ER -

Solvatomorphism of moxidectin

Abstract

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