TY - JOUR
T1 - Sexual dimorphism in the regulation of cell turnover during liver hyperplasia
AU - Tessitore, Luciana
AU - Sesca, Eliana
AU - Pani, Paolo
AU - Dianzani, Mario U.
N1 - Funding Information:
Work supported by Minister0 dell’Universit8 e della Ricerca Scientifica e Tec-nologica (60% and 40% funds) and C.N.R. (Progetto Finalizzato Oncologia ‘ACRO’ and FATMA n. 93.00643,P F41), Rome; Associazione Italiana per la Ricerca sul Cancro Milan.
PY - 1995/6/30
Y1 - 1995/6/30
N2 - A sexual dimorphism occurs in liver cell proliferation following partial hepatectomy, female liver regenerating faster than male, while a continuous excess of choline to females shifts their growth pattern toward that of males (L. Tessitore, P. Pani and M.U. Dianzani, Carcinogenesis, 13 (1992) 1929). In this study we have investigated (a) if the same sexual modulation occurs in a different type of liver growth, hyperplasia induced by a direct mitogen and (b) if the pre-administration of choline to females is able to modulate this dimorphism. Liver hyperplasia induced by lead nitrate, a potent mitogen, has also shown a peculiar sexual dimorphism in all phases of the proliferative process. In contrast with liver regeneration after partial hepatectomy, the mitogenic action of lead nitrate was less effective and was delayed in females as compared with males, by evaluating liver weight, protein accumulation, DNA synthesis and mitotic index. These results were also confirmed by the trend of liver regression by apoptosis. The apoptotic index was higher in males than in females. A prolonged administration of an excess of choline has partially filled these sexual differences, since choline has moved, in females, all the observed parameters (liver weight, protein accumulation, DNA synthesis, mitotic and apoptotic indexes) to values closer to those observed in males.
AB - A sexual dimorphism occurs in liver cell proliferation following partial hepatectomy, female liver regenerating faster than male, while a continuous excess of choline to females shifts their growth pattern toward that of males (L. Tessitore, P. Pani and M.U. Dianzani, Carcinogenesis, 13 (1992) 1929). In this study we have investigated (a) if the same sexual modulation occurs in a different type of liver growth, hyperplasia induced by a direct mitogen and (b) if the pre-administration of choline to females is able to modulate this dimorphism. Liver hyperplasia induced by lead nitrate, a potent mitogen, has also shown a peculiar sexual dimorphism in all phases of the proliferative process. In contrast with liver regeneration after partial hepatectomy, the mitogenic action of lead nitrate was less effective and was delayed in females as compared with males, by evaluating liver weight, protein accumulation, DNA synthesis and mitotic index. These results were also confirmed by the trend of liver regression by apoptosis. The apoptotic index was higher in males than in females. A prolonged administration of an excess of choline has partially filled these sexual differences, since choline has moved, in females, all the observed parameters (liver weight, protein accumulation, DNA synthesis, mitotic and apoptotic indexes) to values closer to those observed in males.
KW - Choline
KW - Liver hyperplasia
KW - Sexual dimorphism
UR - http://www.scopus.com/inward/record.url?scp=0029016843&partnerID=8YFLogxK
U2 - 10.1016/0009-2797(94)03602-1
DO - 10.1016/0009-2797(94)03602-1
M3 - Article
SN - 0009-2797
VL - 97
SP - 1
EP - 10
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 1
ER -