Severe platelet dysfunction in a patient with autoantibodies against membrane glycoproteins IIb-IIIa

C. L. Balduini, G. Grignani, F. Sinigaglia, A. Bisio, L. Pacchiarini, D. Rota Scalabrini, C. Mauri, E. Ascari

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A young woman affected by Hodgkin's disease developed chronic autoimmune thrombocytopenic purpura. Splenectomy induced normalization of her platelet count, but hemorrhagic symptoms did not disappear. The patient's platelets did not aggregate in response to collagen and ADP and the IgG fraction of the patient's plasma induced the same defect in normal platelets. The women's IgG recognized glycoproteins IIb and IIIa of normal platelet membranes. Prednisone therapy induced the disappearance of bleeding symptoms and the normalization of platelet aggregation.

Lingua originaleInglese
pagine (da-a)98-104
Numero di pagine7
RivistaHaemostasis
Volume17
Numero di pubblicazione1-2
DOI
Stato di pubblicazionePubblicato - 1987
Pubblicato esternamente

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