TY - JOUR
T1 - SETIL
T2 - Italian multicentric epidemiological case-control study on risk factors for childhood leukaemia, non hodgkin lymphoma and neuroblastoma: study population and prevalence of risk factors in Italy
AU - Magnani, Corrado
AU - Mattioli, Stefano
AU - Miligi, Lucia
AU - Ranucci, Alessandra
AU - Rondelli, Roberto
AU - Salvan, Alberto
AU - Bisanti, Luigi
AU - Masera, Giuseppe
AU - Rizzari, Carmelo
AU - Zambon, Paola
AU - Cannizzaro, Santina
AU - Gafà, Lorenzo
AU - Luzzatto, Lia L.idia
AU - Benvenuti, Alessandra
AU - Michelozzi, Paola
AU - Kirchmayer, Ursula
AU - Cocco, Pierluigi
AU - Biddau, Pierfranco
AU - Galassi, Claudia
AU - Celentano, Egidio
AU - Guarino, Erni
AU - Assennato, Giorgio
AU - de Nichilo, Gigliola
AU - Merlo, Domenico F.ranco
AU - Bocchini, Vittorio
AU - Pannelli, Franco
AU - Mosciatti, Paola
AU - Minelli, Liliana
AU - Chiavarini, Manuela
AU - Cuttini, Marina
AU - Casotto, Veronica
AU - Torregrossa, Maria V.aleria
AU - Valenti, Rosalia M.aria
AU - Forastiere, Francesco
AU - Haupt, Riccardo
AU - Lagorio, Susanna
AU - Risica, Serena
AU - Polichetti, Alessandro
N1 - Funding Information:
Our heartfelt thanks to the children who participated in the SETIL study and their families. The SETIL study was financially supported by research grants received by AIRC (Italian Association on Research on Cancer), MIUR (Ministry for Instruction, University and Research, PRIN Program), Ministry of Health (Ricerca Sanitaria Finalizzata Program), Ministry of Labour and Welfare, Associazione Neuroblastoma, Piemonte Region (Ricerca Sanitaria Finalizzata Regione Piemonte Program), Liguria Region, Comitato per la vita “Daniele Chianelli”-Associazione per la Ricerca e la Cura delle Leucemie, Linfomi e Tumori di Adulti e Bambini, (Perugia). A special thank to Ms. Victoria Franzinetti for her careful revision of the manuscript.
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Aetiology of childhood leukaemia and childhood neoplasm is poorly understood. Information on the prevalence of risk factors in the childhood population is limited. SETIL is a population based case-control study on childhood leukaemia, conducted with two companion studies on non-Hodgkin Lymphoma (NHL) and neuroblastoma. The study relies on questionnaire interviews and 50 Hz magnetic field (ELF-MF) indoor measurements. This paper discusses the SETIL study design and includes descriptive information.METHODS: The study was carried out in 14 Italian regions (78.3% of Italian population aged 0-10). It included leukaemia, NHL and neuroblastoma cases incident in 0-10 year olds in 1998-2001, registered by the Italian Association of Paediatric Haematology and Oncology (AIEOP) (accrual over 95% of estimated incidence). Two controls for each leukaemia case were randomly sampled from the Local Health Authorities rolls, matched by gender, birthdate and residence. The same controls were used in NHL and neuroblastoma studies. Parents were interviewed at home on: physical agents (ELF-MF and ionizing radiation), chemicals (smoking, solvents, traffic, insecticides), occupation, medical and personal history of children and parents, infectious diseases, immunizations and associated factors. Occupational exposure was collected using job specific modules. ELF-MF was measured in the main rooms (spot measurement) and close to child's bed (48 hours measurement).RESULTS: The study included: 683 leukaemia cases (87% ALL, 13% AnLL), 97 NHL, 155 neuroblastomas, and 1044 controls.CONCLUSIONS: SETIL represents a data source on exposure of Italian children to a broad array of potential carcinogenic factors.
AB - BACKGROUND: Aetiology of childhood leukaemia and childhood neoplasm is poorly understood. Information on the prevalence of risk factors in the childhood population is limited. SETIL is a population based case-control study on childhood leukaemia, conducted with two companion studies on non-Hodgkin Lymphoma (NHL) and neuroblastoma. The study relies on questionnaire interviews and 50 Hz magnetic field (ELF-MF) indoor measurements. This paper discusses the SETIL study design and includes descriptive information.METHODS: The study was carried out in 14 Italian regions (78.3% of Italian population aged 0-10). It included leukaemia, NHL and neuroblastoma cases incident in 0-10 year olds in 1998-2001, registered by the Italian Association of Paediatric Haematology and Oncology (AIEOP) (accrual over 95% of estimated incidence). Two controls for each leukaemia case were randomly sampled from the Local Health Authorities rolls, matched by gender, birthdate and residence. The same controls were used in NHL and neuroblastoma studies. Parents were interviewed at home on: physical agents (ELF-MF and ionizing radiation), chemicals (smoking, solvents, traffic, insecticides), occupation, medical and personal history of children and parents, infectious diseases, immunizations and associated factors. Occupational exposure was collected using job specific modules. ELF-MF was measured in the main rooms (spot measurement) and close to child's bed (48 hours measurement).RESULTS: The study included: 683 leukaemia cases (87% ALL, 13% AnLL), 97 NHL, 155 neuroblastomas, and 1044 controls.CONCLUSIONS: SETIL represents a data source on exposure of Italian children to a broad array of potential carcinogenic factors.
UR - https://www.scopus.com/pages/publications/84996572366
U2 - 10.1186/s13052-014-0103-5
DO - 10.1186/s13052-014-0103-5
M3 - Article
SN - 1720-8424
VL - 40
SP - 103
JO - Italian Journal of Pediatrics
JF - Italian Journal of Pediatrics
ER -
