SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Giovanni Appendino; Simona Prosperini; Carola Valdivia; Mauro Ballero; Giampiero Colombano; Richard A. Billington; Armando A. Genazzani; Olov Sterner

doi:10.1021/np050115m

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Giovanni Appendino
, Simona Prosperini
, Carola Valdivia
, Mauro Ballero
, Giampiero Colombano
, Richard A. Billington
, Armando A. Genazzani
, Olov Sterner

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

Lingua originale	Inglese
pagine (da-a)	1213-1217
Numero di pagine	5
Rivista	Journal of Natural Products
Volume	68
Numero di pubblicazione	8
DOI	https://doi.org/10.1021/np050115m
Stato di pubblicazione	Pubblicato - ago 2005

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10.1021/np050115m

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title = "SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis",

abstract = "An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.",

author = "Giovanni Appendino and Simona Prosperini and Carola Valdivia and Mauro Ballero and Giampiero Colombano and Billington, \{Richard A.\} and Genazzani, \{Armando A.\} and Olov Sterner",

year = "2005",

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doi = "10.1021/np050115m",

language = "English",

volume = "68",

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AU - Appendino, Giovanni

AU - Prosperini, Simona

AU - Valdivia, Carola

AU - Ballero, Mauro

AU - Colombano, Giampiero

AU - Billington, Richard A.

AU - Genazzani, Armando A.

AU - Sterner, Olov

PY - 2005/8

Y1 - 2005/8

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AB - An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

UR - https://www.scopus.com/pages/publications/24744471405

U2 - 10.1021/np050115m

DO - 10.1021/np050115m

M3 - Article

SN - 0163-3864

VL - 68

SP - 1213

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 8

ER -

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Abstract

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