SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Giovanni Appendino, Simona Prosperini, Carola Valdivia, Mauro Ballero, Giampiero Colombano, Richard A. Billington, Armando A. Genazzani, Olov Sterner

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

Lingua originaleInglese
pagine (da-a)1213-1217
Numero di pagine5
RivistaJournal of Natural Products
Volume68
Numero di pubblicazione8
DOI
Stato di pubblicazionePubblicato - ago 2005

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