Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

LA Kiemeney; S Thorlacius; P Sulem; F Geller; KK Aben; SN Stacey; J Gudmundsson; M Jakobsdottir; JT Bergthorsson; A Sigurdsson; T Blondal; JA Witjes; SH Vermeulen; van de Kaa CA Hulsbergen; DW Swinkels; M Ploeg; EB Cornel; H Vergunst; TE Thorgeirsson; D Gudbjartsson; SA Gudjonsson; G Thorleifsson; KT Kristinsson; M Mouy; S Snorradottir; D Placidi; M Campagna; C Arici; K Koppova; E Gurzau; P Rudnai; E Kellen; Silvia POLIDORO; GUARRERA Simonetta; Carlotta SACERDOTE; M Sanchez; B Saez; G Valdivia; C Ryk; Verdier P de; A Lindblom; K Golka; DT Bishop; MA Knowles; S Nikulasson; V Petursdottir; E Jonsson; G Geirsson; B Kristjansson; JI Mayordomo; G Steineck; S Porru; F Buntinx; MP Zeegers; T Fletcher; R Kumar; MATULLO Giuseppe; VINEIS Paolo; AE Kiltie; JR Gulcher; U Thorsteinsdottir; A Kong; T Rafnar; K. Stefansson

doi:10.1038/ng.229

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

LA Kiemeney, S Thorlacius, P Sulem, F Geller, KK Aben, SN Stacey, J Gudmundsson, M Jakobsdottir, JT Bergthorsson, A Sigurdsson, T Blondal, JA Witjes, SH Vermeulen, van de Kaa CA Hulsbergen, DW Swinkels, M Ploeg, EB Cornel, H Vergunst, TE Thorgeirsson, D GudbjartssonSA Gudjonsson, G Thorleifsson, KT Kristinsson, M Mouy, S Snorradottir, D Placidi, M Campagna, C Arici, K Koppova, E Gurzau, P Rudnai, E Kellen, Silvia POLIDORO, GUARRERA Simonetta, Carlotta SACERDOTE, M Sanchez, B Saez, G Valdivia, C Ryk, Verdier P de, A Lindblom, K Golka, DT Bishop, MA Knowles, S Nikulasson, V Petursdottir, E Jonsson, G Geirsson, B Kristjansson, JI Mayordomo, G Steineck, S Porru, F Buntinx, MP Zeegers, T Fletcher, R Kumar, MATULLO Giuseppe, VINEIS Paolo, AE Kiltie, JR Gulcher, U Thorsteinsdottir, A Kong, T Rafnar, K. Stefansson

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).

Lingua originale	Inglese
pagine (da-a)	1307-1312
Numero di pagine	6
Rivista	Nature Genetics
Volume	40
Numero di pubblicazione	11
DOI	https://doi.org/10.1038/ng.229
Stato di pubblicazione	Pubblicato - 2008

Keywords

Bladder cancer
Genome-wide association study
8q24

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1038/ng.229

Altri file e collegamenti

handle

Cita questo

Kiemeney, LA., Thorlacius, S., Sulem, P., Geller, F., Aben, KK., Stacey, SN., Gudmundsson, J., Jakobsdottir, M., Bergthorsson, JT., Sigurdsson, A., Blondal, T., Witjes, JA., Vermeulen, SH., Hulsbergen, V. D. K. CA., Swinkels, DW., Ploeg, M., Cornel, EB., Vergunst, H., Thorgeirsson, TE., ... Stefansson, K. (2008). Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nature Genetics, 40(11), 1307-1312. https://doi.org/10.1038/ng.229

@article{65bba7737b264861bb3fd4d03d84745f,

title = "Sequence variant on 8q24 confers susceptibility to urinary bladder cancer",

abstract = "We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).",

keywords = "Bladder cancer, Genome-wide association study, 8q24, Bladder cancer, Genome-wide association study, 8q24",

author = "LA Kiemeney and S Thorlacius and P Sulem and F Geller and KK Aben and SN Stacey and J Gudmundsson and M Jakobsdottir and JT Bergthorsson and A Sigurdsson and T Blondal and JA Witjes and SH Vermeulen and Hulsbergen, {van de Kaa CA} and DW Swinkels and M Ploeg and EB Cornel and H Vergunst and TE Thorgeirsson and D Gudbjartsson and SA Gudjonsson and G Thorleifsson and KT Kristinsson and M Mouy and S Snorradottir and D Placidi and M Campagna and C Arici and K Koppova and E Gurzau and P Rudnai and E Kellen and Silvia POLIDORO and GUARRERA Simonetta and Carlotta SACERDOTE and M Sanchez and B Saez and G Valdivia and C Ryk and de, {Verdier P} and A Lindblom and K Golka and DT Bishop and MA Knowles and S Nikulasson and V Petursdottir and E Jonsson and G Geirsson and B Kristjansson and JI Mayordomo and G Steineck and S Porru and F Buntinx and MP Zeegers and T Fletcher and R Kumar and MATULLO Giuseppe and VINEIS Paolo and AE Kiltie and JR Gulcher and U Thorsteinsdottir and A Kong and T Rafnar and K. Stefansson",

year = "2008",

doi = "10.1038/ng.229",

language = "English",

volume = "40",

pages = "1307--1312",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "11",

}

Kiemeney, LA, Thorlacius, S, Sulem, P, Geller, F, Aben, KK, Stacey, SN, Gudmundsson, J, Jakobsdottir, M, Bergthorsson, JT, Sigurdsson, A, Blondal, T, Witjes, JA, Vermeulen, SH, Hulsbergen, VDKCA, Swinkels, DW, Ploeg, M, Cornel, EB, Vergunst, H, Thorgeirsson, TE, Gudbjartsson, D, Gudjonsson, SA, Thorleifsson, G, Kristinsson, KT, Mouy, M, Snorradottir, S, Placidi, D, Campagna, M, Arici, C, Koppova, K, Gurzau, E, Rudnai, P, Kellen, E, POLIDORO, S, Simonetta, GUARRERA, SACERDOTE, C, Sanchez, M, Saez, B, Valdivia, G, Ryk, C, de, VP, Lindblom, A, Golka, K, Bishop, DT, Knowles, MA, Nikulasson, S, Petursdottir, V, Jonsson, E, Geirsson, G, Kristjansson, B, Mayordomo, JI, Steineck, G, Porru, S, Buntinx, F, Zeegers, MP, Fletcher, T, Kumar, R, Giuseppe, MATULLO, Paolo, VINEIS, Kiltie, AE, Gulcher, JR, Thorsteinsdottir, U, Kong, A, Rafnar, T & Stefansson, K 2008, 'Sequence variant on 8q24 confers susceptibility to urinary bladder cancer', Nature Genetics, vol. 40, n. 11, pagg. 1307-1312. https://doi.org/10.1038/ng.229

TY - JOUR

T1 - Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

AU - Kiemeney, LA

AU - Thorlacius, S

AU - Sulem, P

AU - Geller, F

AU - Aben, KK

AU - Stacey, SN

AU - Gudmundsson, J

AU - Jakobsdottir, M

AU - Bergthorsson, JT

AU - Sigurdsson, A

AU - Blondal, T

AU - Witjes, JA

AU - Vermeulen, SH

AU - Hulsbergen, van de Kaa CA

AU - Swinkels, DW

AU - Ploeg, M

AU - Cornel, EB

AU - Vergunst, H

AU - Thorgeirsson, TE

AU - Gudbjartsson, D

AU - Gudjonsson, SA

AU - Thorleifsson, G

AU - Kristinsson, KT

AU - Mouy, M

AU - Snorradottir, S

AU - Placidi, D

AU - Campagna, M

AU - Arici, C

AU - Koppova, K

AU - Gurzau, E

AU - Rudnai, P

AU - Kellen, E

AU - POLIDORO, Silvia

AU - Simonetta, GUARRERA

AU - SACERDOTE, Carlotta

AU - Sanchez, M

AU - Saez, B

AU - Valdivia, G

AU - Ryk, C

AU - de, Verdier P

AU - Lindblom, A

AU - Golka, K

AU - Bishop, DT

AU - Knowles, MA

AU - Nikulasson, S

AU - Petursdottir, V

AU - Jonsson, E

AU - Geirsson, G

AU - Kristjansson, B

AU - Mayordomo, JI

AU - Steineck, G

AU - Porru, S

AU - Buntinx, F

AU - Zeegers, MP

AU - Fletcher, T

AU - Kumar, R

AU - Giuseppe, MATULLO

AU - Paolo, VINEIS

AU - Kiltie, AE

AU - Gulcher, JR

AU - Thorsteinsdottir, U

AU - Kong, A

AU - Rafnar, T

AU - Stefansson, K.

PY - 2008

Y1 - 2008

N2 - We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).

AB - We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).

KW - Bladder cancer

KW - Genome-wide association study

KW - 8q24

KW - Bladder cancer

KW - Genome-wide association study

KW - 8q24

UR - https://iris.uniupo.it/handle/null

U2 - 10.1038/ng.229

DO - 10.1038/ng.229

M3 - Article

SN - 1061-4036

VL - 40

SP - 1307

EP - 1312

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo