Risultati della radioterapia nel trattamento dei tumori maligni della fossa nasale e del vestibolo.

P. Gabriele, R. Orecchia, G. Valente, M. G. Ruo Redda, P. Pisani, M. Krengli, G. L. Negri

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The authors report their personal experience in the treatment of malignant tumors of the nasal cavity and vestibule with irradiation alone or combined with surgery. From January 1976 to December 1989 we treated 40 patients with 22 squamous cell carcinomas, 12 adenocarcinomas or other glandular types, and 6 other histologic types of lesions: 23 patients received irradiation alone and 17 patients were treated with surgery and postoperative irradiation. The protocol included surgery as the treatment of choice: irradiation alone was administered to inoperable tumors or to the patients refusing surgery; postoperative irradiation was given when macroscopic or microscopic residual disease was observed after surgery or to particular histologic types. In the whole series of patients, 3- and 5-year local control rates were 70% and 50%, respectively; better results were obtained in the patients receiving the combined treatment (64% at 5 years) than in the patients receiving irradiation alone (43% at 5 years). Disease stages (I and II versus III and IV) were the only statistically significant prognostic factor; worse results in irradiated patients might be due to the higher rate of advanced lesions in this group. Salvage therapy (irradiation in 8 cases, surgery in 2 and chemotherapy in 1) was successfully performed in 5 of 11 treated patients. The 3- and 5-year overall survival rates were 88% and 70%, respectively. Severe complication rate was lower than 10% (3 cases only).

Titolo tradotto del contributoRadiotherapy results in the treatment of malignant tumors of the nasal fossa and vestibule
Lingua originaleItalian
pagine (da-a)853-857
Numero di pagine5
RivistaRadiologia Medica
Volume87
Numero di pubblicazione6
Stato di pubblicazionePubblicato - giu 1994
Pubblicato esternamente

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