Risk of second malignant neoplasms after childhood central nervous system malignant tumours: An international study

M. Maule; G. Scélo; G. Pastore; P. Brennan; K. Hemminki; E. Pukkala; E. Weiderpass; J. H. Olsen; E. Tracey; M. L. McBride; D. H. Brewster; V. Pompe-Kirn; J. M. Tonita; E. V. Kliewer; K. S. Chia; J. G. Jonasson; C. Martos; C. Magnani; P. Boffetta

doi:10.1016/j.ejca.2008.02.012

Risk of second malignant neoplasms after childhood central nervous system malignant tumours: An international study

M. Maule, G. Scélo, G. Pastore, P. Brennan, K. Hemminki, E. Pukkala, E. Weiderpass, J. H. Olsen, E. Tracey, M. L. McBride, D. H. Brewster, V. Pompe-Kirn, J. M. Tonita, E. V. Kliewer, K. S. Chia, J. G. Jonasson, C. Martos, C. Magnani, P. Boffetta

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Purpose: The aim of this study was to assess the risk of second malignant neoplasms (SMNs) other than central nervous system (CNS) neoplasms after childhood CNS cancer in an international multicentre study. Methods: Individual data on cases of CNS cancer in children (0-14 years) and on subsequent SMNs were obtained from 13 population-based cancer registries contributing data for different time periods in 1943-2000. Standardised incidence ratios (SIRs) with 95% confidence intervals (CI), absolute excess risk and cumulative incidence of SMNs were computed. Results: We observed 43 SMNs in 8431 CNS cancer survivors. The SIR was 10.6 (4.85-20.1) for thyroid cancer (nine cases), 2.75 (1.01-5.99) for leukaemia (six cases) and 2.47 (0.90-5.37) for lymphoma (six cases). The SIRs were highest in the first 10 years after CNS cancer diagnosis. The cumulative incidence of non-CNS SMNs was 3.30% (0.95-5.65%) within 45 years after a CNS cancer diagnosis. Within 15 years, the cumulative incidence was highest for cases diagnosed after 1980 (0.56%, 95% CI: 0.29-0.82%). Conclusion: This population-based study indicates that about one every 180 survivors of a childhood CNS cancer will develop a non-CNS SMN within the following 15 years. The excess is higher after glioma and embryonal malignant tumour than after another CNS tumour.

Lingua originale	Inglese
pagine (da-a)	830-839
Numero di pagine	10
Rivista	European Journal of Cancer
Volume	44
Numero di pubblicazione	6
DOI	https://doi.org/10.1016/j.ejca.2008.02.012
Stato di pubblicazione	Pubblicato - apr 2008
Pubblicato esternamente	Sì

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10.1016/j.ejca.2008.02.012

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Maule, M., Scélo, G., Pastore, G., Brennan, P., Hemminki, K., Pukkala, E., Weiderpass, E., Olsen, J. H., Tracey, E., McBride, M. L., Brewster, D. H., Pompe-Kirn, V., Tonita, J. M., Kliewer, E. V., Chia, K. S., Jonasson, J. G., Martos, C., Magnani, C., & Boffetta, P. (2008). Risk of second malignant neoplasms after childhood central nervous system malignant tumours: An international study. European Journal of Cancer, 44(6), 830-839. https://doi.org/10.1016/j.ejca.2008.02.012

@article{68d2fc65da0e4bc9a49381826837d4bb,

title = "Risk of second malignant neoplasms after childhood central nervous system malignant tumours: An international study",

abstract = "Purpose: The aim of this study was to assess the risk of second malignant neoplasms (SMNs) other than central nervous system (CNS) neoplasms after childhood CNS cancer in an international multicentre study. Methods: Individual data on cases of CNS cancer in children (0-14 years) and on subsequent SMNs were obtained from 13 population-based cancer registries contributing data for different time periods in 1943-2000. Standardised incidence ratios (SIRs) with 95% confidence intervals (CI), absolute excess risk and cumulative incidence of SMNs were computed. Results: We observed 43 SMNs in 8431 CNS cancer survivors. The SIR was 10.6 (4.85-20.1) for thyroid cancer (nine cases), 2.75 (1.01-5.99) for leukaemia (six cases) and 2.47 (0.90-5.37) for lymphoma (six cases). The SIRs were highest in the first 10 years after CNS cancer diagnosis. The cumulative incidence of non-CNS SMNs was 3.30% (0.95-5.65%) within 45 years after a CNS cancer diagnosis. Within 15 years, the cumulative incidence was highest for cases diagnosed after 1980 (0.56%, 95% CI: 0.29-0.82%). Conclusion: This population-based study indicates that about one every 180 survivors of a childhood CNS cancer will develop a non-CNS SMN within the following 15 years. The excess is higher after glioma and embryonal malignant tumour than after another CNS tumour.",

keywords = "Childhood cancer, Neoplasms, Primary central nervous system neoplasms, Second primary",

author = "M. Maule and G. Sc{\'e}lo and G. Pastore and P. Brennan and K. Hemminki and E. Pukkala and E. Weiderpass and Olsen, {J. H.} and E. Tracey and McBride, {M. L.} and Brewster, {D. H.} and V. Pompe-Kirn and Tonita, {J. M.} and Kliewer, {E. V.} and Chia, {K. S.} and Jonasson, {J. G.} and C. Martos and C. Magnani and P. Boffetta",

note = "Funding Information: The analysis was supported by a R03 Grant to IARC by the US NCI (Grant No. CA101442-02). The work of Milena Maule was supported by Compagnia di San Paolo FIRMS, the Italian Association for Cancer Research, and the Piedmont Region. The funding agencies had no role in the design of this study, data collection, analysis and interpretation of the results, or the writing of the manuscript. We acknowledge the work of Didier Colin, IARC, for initial preparation of the data set. We thank Franco Merletti and Benedetto Terracini for useful discussions and suggestions.",

year = "2008",

month = apr,

doi = "10.1016/j.ejca.2008.02.012",

language = "English",

volume = "44",

pages = "830--839",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd.",

number = "6",

}

Maule, M, Scélo, G, Pastore, G, Brennan, P, Hemminki, K, Pukkala, E, Weiderpass, E, Olsen, JH, Tracey, E, McBride, ML, Brewster, DH, Pompe-Kirn, V, Tonita, JM, Kliewer, EV, Chia, KS, Jonasson, JG, Martos, C, Magnani, C & Boffetta, P 2008, 'Risk of second malignant neoplasms after childhood central nervous system malignant tumours: An international study', European Journal of Cancer, vol. 44, n. 6, pagg. 830-839. https://doi.org/10.1016/j.ejca.2008.02.012

TY - JOUR

T1 - Risk of second malignant neoplasms after childhood central nervous system malignant tumours

T2 - An international study

AU - Maule, M.

AU - Scélo, G.

AU - Pastore, G.

AU - Brennan, P.

AU - Hemminki, K.

AU - Pukkala, E.

AU - Weiderpass, E.

AU - Olsen, J. H.

AU - Tracey, E.

AU - McBride, M. L.

AU - Brewster, D. H.

AU - Pompe-Kirn, V.

AU - Tonita, J. M.

AU - Kliewer, E. V.

AU - Chia, K. S.

AU - Jonasson, J. G.

AU - Martos, C.

AU - Magnani, C.

AU - Boffetta, P.

N1 - Funding Information: The analysis was supported by a R03 Grant to IARC by the US NCI (Grant No. CA101442-02). The work of Milena Maule was supported by Compagnia di San Paolo FIRMS, the Italian Association for Cancer Research, and the Piedmont Region. The funding agencies had no role in the design of this study, data collection, analysis and interpretation of the results, or the writing of the manuscript. We acknowledge the work of Didier Colin, IARC, for initial preparation of the data set. We thank Franco Merletti and Benedetto Terracini for useful discussions and suggestions.

PY - 2008/4

Y1 - 2008/4

N2 - Purpose: The aim of this study was to assess the risk of second malignant neoplasms (SMNs) other than central nervous system (CNS) neoplasms after childhood CNS cancer in an international multicentre study. Methods: Individual data on cases of CNS cancer in children (0-14 years) and on subsequent SMNs were obtained from 13 population-based cancer registries contributing data for different time periods in 1943-2000. Standardised incidence ratios (SIRs) with 95% confidence intervals (CI), absolute excess risk and cumulative incidence of SMNs were computed. Results: We observed 43 SMNs in 8431 CNS cancer survivors. The SIR was 10.6 (4.85-20.1) for thyroid cancer (nine cases), 2.75 (1.01-5.99) for leukaemia (six cases) and 2.47 (0.90-5.37) for lymphoma (six cases). The SIRs were highest in the first 10 years after CNS cancer diagnosis. The cumulative incidence of non-CNS SMNs was 3.30% (0.95-5.65%) within 45 years after a CNS cancer diagnosis. Within 15 years, the cumulative incidence was highest for cases diagnosed after 1980 (0.56%, 95% CI: 0.29-0.82%). Conclusion: This population-based study indicates that about one every 180 survivors of a childhood CNS cancer will develop a non-CNS SMN within the following 15 years. The excess is higher after glioma and embryonal malignant tumour than after another CNS tumour.

AB - Purpose: The aim of this study was to assess the risk of second malignant neoplasms (SMNs) other than central nervous system (CNS) neoplasms after childhood CNS cancer in an international multicentre study. Methods: Individual data on cases of CNS cancer in children (0-14 years) and on subsequent SMNs were obtained from 13 population-based cancer registries contributing data for different time periods in 1943-2000. Standardised incidence ratios (SIRs) with 95% confidence intervals (CI), absolute excess risk and cumulative incidence of SMNs were computed. Results: We observed 43 SMNs in 8431 CNS cancer survivors. The SIR was 10.6 (4.85-20.1) for thyroid cancer (nine cases), 2.75 (1.01-5.99) for leukaemia (six cases) and 2.47 (0.90-5.37) for lymphoma (six cases). The SIRs were highest in the first 10 years after CNS cancer diagnosis. The cumulative incidence of non-CNS SMNs was 3.30% (0.95-5.65%) within 45 years after a CNS cancer diagnosis. Within 15 years, the cumulative incidence was highest for cases diagnosed after 1980 (0.56%, 95% CI: 0.29-0.82%). Conclusion: This population-based study indicates that about one every 180 survivors of a childhood CNS cancer will develop a non-CNS SMN within the following 15 years. The excess is higher after glioma and embryonal malignant tumour than after another CNS tumour.

KW - Childhood cancer

KW - Neoplasms

KW - Primary central nervous system neoplasms

KW - Second primary

UR - http://www.scopus.com/inward/record.url?scp=41949134625&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2008.02.012

DO - 10.1016/j.ejca.2008.02.012

M3 - Article

SN - 0959-8049

VL - 44

SP - 830

EP - 839

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 6

ER -

Risk of second malignant neoplasms after childhood central nervous system malignant tumours: An international study

Abstract

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