Risk of neuroblastoma, maternal characteristics and perinatal exposures: The SETIL study.

S Parodi; Merlo DF; A Ranucci; L Miligi; A Benvenuti; R Rondelli; Corrado MAGNANI; R Haupt; SETIL Working Group; C Magnani; S Mattioli; L Miligi; A Ranucci; R Rondelli; A Salvan; G Masera; C Rizzari; L Bisanti; P Zambon; Veneto A Greco; S Cannizzaro; L Gafà; Luzzatto LL; A Benvenuti; P Michelozzi; U Kirchmayer; P Cocco; C Galassi; E Celentano; E Guarino; G Assennato; G de Nichilo; Merlo DF; V Bocchini; P Mosciatti; S Pubblica; L Minelli; M Chiavarini; M Cuttini; V Casotto; Torregrossa MV; Valenti RM; F Forastiere; R Haupt; S Lagorio; S Risica; A Polichetti; F Bochicchio; C Nuccetelli; P Biddau; M Aricò; DeSalvo GL; F Locatelli; A Pession; S Varotto; V Poggi; P Massaglia; D Monetti; R Targhetta; G Bernini; A Lippi; M Nardi; A Acquaviva; F Pannelli; R Tumori; G Sampietro; G Schilirò; A Pulsoni; P Legittimo; Francesco BARONE ADESI; F Cavariani; I Belletti; L Troeschel; R Calisti; C Marche; S Silvestri; L Sommani; A Farioli; Tozzi GA; B Terracini; G Paolucci; D Andreuccetti; L Anglesio; M Bertolotti; P Bevitori; R Biancotto; A Biggeri; S Bucci; R Calisti; P Comba; P Crosignani; G d'Amore; E Duglio; M Erna; Daniela FERRANTE; L Gelli; M Gilardetti; P Guidotti; M Lombardi; D Loomis; M Magnoni; F Merletti; G Miceli; D Monetti; P Mozzo; M Nardi; S Panico; A Poggi; O Pons; A Rasulo; S Roletti; M Rosa; V Mestre; O Ru; G Russo; G Sgorbati; L Simonato; D Sivo; B Stievano; S Tofani; F Troti; R Tumino; M Valle; P Vecchia; G Erminio; B. Galleni

doi:10.1016/j.canep.2014.09.007

Risk of neuroblastoma, maternal characteristics and perinatal exposures: The SETIL study.

S Parodi, Merlo DF, A Ranucci, L Miligi, A Benvenuti, R Rondelli, Corrado MAGNANI, R Haupt, SETIL Working Group, C Magnani, S Mattioli, L Miligi, A Ranucci, R Rondelli, A Salvan, G Masera, C Rizzari, L Bisanti, P Zambon, Veneto A GrecoS Cannizzaro, L Gafà, Luzzatto LL, A Benvenuti, P Michelozzi, U Kirchmayer, P Cocco, C Galassi, E Celentano, E Guarino, G Assennato, G de Nichilo, Merlo DF, V Bocchini, P Mosciatti, S Pubblica, L Minelli, M Chiavarini, M Cuttini, V Casotto, Torregrossa MV, Valenti RM, F Forastiere, R Haupt, S Lagorio, S Risica, A Polichetti, F Bochicchio, C Nuccetelli, P Biddau, M Aricò, DeSalvo GL, F Locatelli, A Pession, S Varotto, V Poggi, P Massaglia, D Monetti, R Targhetta, G Bernini, A Lippi, M Nardi, A Acquaviva, F Pannelli, R Tumori, G Sampietro, G Schilirò, A Pulsoni, P Legittimo, Francesco BARONE ADESI, F Cavariani, I Belletti, L Troeschel, R Calisti, C Marche, S Silvestri, L Sommani, A Farioli, Tozzi GA, B Terracini, G Paolucci, D Andreuccetti, L Anglesio, M Bertolotti, P Bevitori, R Biancotto, A Biggeri, S Bucci, R Calisti, P Comba, P Crosignani, G d'Amore, E Duglio, M Erna, Daniela FERRANTE, L Gelli, M Gilardetti, P Guidotti, M Lombardi, D Loomis, M Magnoni, F Merletti, G Miceli, D Monetti, P Mozzo, M Nardi, S Panico, A Poggi, O Pons, A Rasulo, S Roletti, M Rosa, V Mestre, O Ru, G Russo, G Sgorbati, L Simonato, D Sivo, B Stievano, S Tofani, F Troti, R Tumino, M Valle, P Vecchia, G Erminio, B. Galleni

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Neuroblastoma (NB) is the most common extra-cranial paediatric solid tumour. Incidence peaks in infancy, suggesting a role of in-utero and neonatal exposures but its aetiology is largely unknown. The aim of the present study is to evaluate the association between maternal characteristics and perinatal factors with the risk of NB, using data from the SETIL database.SETIL is a large Italian population-based case-control study established to evaluate several potential cancer risk factors in 0-10 year olds. Information about maternal characteristics, reproductive history, environmental and occupational exposures during pregnancy, as well as newborns' characteristics were obtained using a structured questionnaire. Extremely low frequency magnetic field (ELF-MF) home exposure was measured. The study included 1044 healthy controls and 153 NB cases, diagnosed between 1998 and 2001.A twofold risk was associated to exposure in pregnancy to chemical products for domestic work and to hair dye. The risk associated with the latter was higher among 0-17 month old children (OR=5.5, 95\%CI: 1.0-29.3). Risk was increased for children whose mothers had suffered work related exposure in the preconception period to solvents (OR=2.0 95\%CI: 1.0-4.1) and in particular to aromatic hydrocarbons (OR=9.2, 95\%CI: 2.4-34.3). No association was observed with ELF-MF exposure. A higher risk was found among children with congenital malformations (OR=4.9, 95\%CI: 1.8-13.6) or neurofibromatosis (2 cases and 0 controls, p=0.016).Our study suggests maternal exposure to hair dyes and aromatic hydrocarbons plays a role and deserves further investigation. The association with congenital malformations might also be explained by over-diagnosis. External exposure, in particular during and before pregnancy might contribute to NB occurrence.

Lingua originale	Inglese
pagine (da-a)	686-694
Numero di pagine	9
Rivista	Cancer Epidemiology
Volume	38
Numero di pubblicazione	6
DOI	https://doi.org/10.1016/j.canep.2014.09.007
Stato di pubblicazione	Pubblicato - 2014

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10.1016/j.canep.2014.09.007

http://hdl.handle.net/11579/56792

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Parodi, S., DF, M., Ranucci, A., Miligi, L., Benvenuti, A., Rondelli, R., MAGNANI, C., Haupt, R., Group, SETIL. W., Magnani, C., Mattioli, S., Miligi, L., Ranucci, A., Rondelli, R., Salvan, A., Masera, G., Rizzari, C., Bisanti, L., Zambon, P., ... Galleni, B. (2014). Risk of neuroblastoma, maternal characteristics and perinatal exposures: The SETIL study. Cancer Epidemiology, 38(6), 686-694. https://doi.org/10.1016/j.canep.2014.09.007

@article{8c72f04a68e14e37a952db6b5486404d,

title = "Risk of neuroblastoma, maternal characteristics and perinatal exposures: The SETIL study.",

abstract = "Neuroblastoma (NB) is the most common extra-cranial paediatric solid tumour. Incidence peaks in infancy, suggesting a role of in-utero and neonatal exposures but its aetiology is largely unknown. The aim of the present study is to evaluate the association between maternal characteristics and perinatal factors with the risk of NB, using data from the SETIL database.SETIL is a large Italian population-based case-control study established to evaluate several potential cancer risk factors in 0-10 year olds. Information about maternal characteristics, reproductive history, environmental and occupational exposures during pregnancy, as well as newborns' characteristics were obtained using a structured questionnaire. Extremely low frequency magnetic field (ELF-MF) home exposure was measured. The study included 1044 healthy controls and 153 NB cases, diagnosed between 1998 and 2001.A twofold risk was associated to exposure in pregnancy to chemical products for domestic work and to hair dye. The risk associated with the latter was higher among 0-17 month old children (OR=5.5, 95\textbackslash{}\%CI: 1.0-29.3). Risk was increased for children whose mothers had suffered work related exposure in the preconception period to solvents (OR=2.0 95\textbackslash{}\%CI: 1.0-4.1) and in particular to aromatic hydrocarbons (OR=9.2, 95\textbackslash{}\%CI: 2.4-34.3). No association was observed with ELF-MF exposure. A higher risk was found among children with congenital malformations (OR=4.9, 95\textbackslash{}\%CI: 1.8-13.6) or neurofibromatosis (2 cases and 0 controls, p=0.016).Our study suggests maternal exposure to hair dyes and aromatic hydrocarbons plays a role and deserves further investigation. The association with congenital malformations might also be explained by over-diagnosis. External exposure, in particular during and before pregnancy might contribute to NB occurrence.",

author = "S Parodi and Merlo DF and A Ranucci and L Miligi and A Benvenuti and R Rondelli and Corrado MAGNANI and R Haupt and Group, \{SETIL Working\} and C Magnani and S Mattioli and L Miligi and A Ranucci and R Rondelli and A Salvan and G Masera and C Rizzari and L Bisanti and P Zambon and Greco, \{Veneto A\} and S Cannizzaro and L Gaf{\`a} and Luzzatto LL and A Benvenuti and P Michelozzi and U Kirchmayer and P Cocco and C Galassi and E Celentano and E Guarino and G Assennato and \{de Nichilo\}, G and Merlo DF and V Bocchini and P Mosciatti and S Pubblica and L Minelli and M Chiavarini and M Cuttini and V Casotto and Torregrossa MV and Valenti RM and F Forastiere and R Haupt and S Lagorio and S Risica and A Polichetti and F Bochicchio and C Nuccetelli and P Biddau and M Aric{\`o} and DeSalvo GL and F Locatelli and A Pession and S Varotto and V Poggi and P Massaglia and D Monetti and R Targhetta and G Bernini and A Lippi and M Nardi and A Acquaviva and F Pannelli and R Tumori and G Sampietro and G Schilir{\`o} and A Pulsoni and P Legittimo and \{BARONE ADESI\}, Francesco and F Cavariani and I Belletti and L Troeschel and R Calisti and C Marche and S Silvestri and L Sommani and A Farioli and Tozzi GA and B Terracini and G Paolucci and D Andreuccetti and L Anglesio and M Bertolotti and P Bevitori and R Biancotto and A Biggeri and S Bucci and R Calisti and P Comba and P Crosignani and G d'Amore and E Duglio and M Erna and Daniela FERRANTE and L Gelli and M Gilardetti and P Guidotti and M Lombardi and D Loomis and M Magnoni and F Merletti and G Miceli and D Monetti and P Mozzo and M Nardi and S Panico and A Poggi and O Pons and A Rasulo and S Roletti and M Rosa and V Mestre and O Ru and G Russo and G Sgorbati and L Simonato and D Sivo and B Stievano and S Tofani and F Troti and R Tumino and M Valle and P Vecchia and G Erminio and B. Galleni",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

year = "2014",

doi = "10.1016/j.canep.2014.09.007",

language = "English",

volume = "38",

pages = "686--694",

journal = "Cancer Epidemiology",

issn = "1877-7821",

publisher = "Elsevier Ltd.",

number = "6",

}

Parodi, S, DF, M, Ranucci, A, Miligi, L, Benvenuti, A, Rondelli, R, MAGNANI, C, Haupt, R, Group, SETILW, Magnani, C, Mattioli, S, Miligi, L, Ranucci, A, Rondelli, R, Salvan, A, Masera, G, Rizzari, C, Bisanti, L, Zambon, P, Greco, VA, Cannizzaro, S, Gafà, L, LL, L, Benvenuti, A, Michelozzi, P, Kirchmayer, U, Cocco, P, Galassi, C, Celentano, E, Guarino, E, Assennato, G, de Nichilo, G, DF, M, Bocchini, V, Mosciatti, P, Pubblica, S, Minelli, L, Chiavarini, M, Cuttini, M, Casotto, V, MV, T, RM, V, Forastiere, F, Haupt, R, Lagorio, S, Risica, S, Polichetti, A, Bochicchio, F, Nuccetelli, C, Biddau, P, Aricò, M, GL, D, Locatelli, F, Pession, A, Varotto, S, Poggi, V, Massaglia, P, Monetti, D, Targhetta, R, Bernini, G, Lippi, A, Nardi, M, Acquaviva, A, Pannelli, F, Tumori, R, Sampietro, G, Schilirò, G, Pulsoni, A, Legittimo, P, BARONE ADESI, F, Cavariani, F, Belletti, I, Troeschel, L, Calisti, R, Marche, C, Silvestri, S, Sommani, L, Farioli, A, GA, T, Terracini, B, Paolucci, G, Andreuccetti, D, Anglesio, L, Bertolotti, M, Bevitori, P, Biancotto, R, Biggeri, A, Bucci, S, Calisti, R, Comba, P, Crosignani, P, d'Amore, G, Duglio, E, Erna, M, FERRANTE, D, Gelli, L, Gilardetti, M, Guidotti, P, Lombardi, M, Loomis, D, Magnoni, M, Merletti, F, Miceli, G, Monetti, D, Mozzo, P, Nardi, M, Panico, S, Poggi, A, Pons, O, Rasulo, A, Roletti, S, Rosa, M, Mestre, V, Ru, O, Russo, G, Sgorbati, G, Simonato, L, Sivo, D, Stievano, B, Tofani, S, Troti, F, Tumino, R, Valle, M, Vecchia, P, Erminio, G & Galleni, B 2014, 'Risk of neuroblastoma, maternal characteristics and perinatal exposures: The SETIL study.', Cancer Epidemiology, vol. 38, n. 6, pagg. 686-694. https://doi.org/10.1016/j.canep.2014.09.007

TY - JOUR

T1 - Risk of neuroblastoma, maternal characteristics and perinatal exposures: The SETIL study.

AU - Parodi, S

AU - DF, Merlo

AU - Ranucci, A

AU - Miligi, L

AU - Benvenuti, A

AU - Rondelli, R

AU - MAGNANI, Corrado

AU - Haupt, R

AU - Group, SETIL Working

AU - Magnani, C

AU - Mattioli, S

AU - Miligi, L

AU - Ranucci, A

AU - Rondelli, R

AU - Salvan, A

AU - Masera, G

AU - Rizzari, C

AU - Bisanti, L

AU - Zambon, P

AU - Greco, Veneto A

AU - Cannizzaro, S

AU - Gafà, L

AU - LL, Luzzatto

AU - Benvenuti, A

AU - Michelozzi, P

AU - Kirchmayer, U

AU - Cocco, P

AU - Galassi, C

AU - Celentano, E

AU - Guarino, E

AU - Assennato, G

AU - de Nichilo, G

AU - DF, Merlo

AU - Bocchini, V

AU - Mosciatti, P

AU - Pubblica, S

AU - Minelli, L

AU - Chiavarini, M

AU - Cuttini, M

AU - Casotto, V

AU - MV, Torregrossa

AU - RM, Valenti

AU - Forastiere, F

AU - Haupt, R

AU - Lagorio, S

AU - Risica, S

AU - Polichetti, A

AU - Bochicchio, F

AU - Nuccetelli, C

AU - Biddau, P

AU - Aricò, M

AU - GL, DeSalvo

AU - Locatelli, F

AU - Pession, A

AU - Varotto, S

AU - Poggi, V

AU - Massaglia, P

AU - Monetti, D

AU - Targhetta, R

AU - Bernini, G

AU - Lippi, A

AU - Nardi, M

AU - Acquaviva, A

AU - Pannelli, F

AU - Tumori, R

AU - Sampietro, G

AU - Schilirò, G

AU - Pulsoni, A

AU - Legittimo, P

AU - BARONE ADESI, Francesco

AU - Cavariani, F

AU - Belletti, I

AU - Troeschel, L

AU - Calisti, R

AU - Marche, C

AU - Silvestri, S

AU - Sommani, L

AU - Farioli, A

AU - GA, Tozzi

AU - Terracini, B

AU - Paolucci, G

AU - Andreuccetti, D

AU - Anglesio, L

AU - Bertolotti, M

AU - Bevitori, P

AU - Biancotto, R

AU - Biggeri, A

AU - Bucci, S

AU - Calisti, R

AU - Comba, P

AU - Crosignani, P

AU - d'Amore, G

AU - Duglio, E

AU - Erna, M

AU - FERRANTE, Daniela

AU - Gelli, L

AU - Gilardetti, M

AU - Guidotti, P

AU - Lombardi, M

AU - Loomis, D

AU - Magnoni, M

AU - Merletti, F

AU - Miceli, G

AU - Monetti, D

AU - Mozzo, P

AU - Nardi, M

AU - Panico, S

AU - Poggi, A

AU - Pons, O

AU - Rasulo, A

AU - Roletti, S

AU - Rosa, M

AU - Mestre, V

AU - Ru, O

AU - Russo, G

AU - Sgorbati, G

AU - Simonato, L

AU - Sivo, D

AU - Stievano, B

AU - Tofani, S

AU - Troti, F

AU - Tumino, R

AU - Valle, M

AU - Vecchia, P

AU - Erminio, G

AU - Galleni, B.

PY - 2014

Y1 - 2014

N2 - Neuroblastoma (NB) is the most common extra-cranial paediatric solid tumour. Incidence peaks in infancy, suggesting a role of in-utero and neonatal exposures but its aetiology is largely unknown. The aim of the present study is to evaluate the association between maternal characteristics and perinatal factors with the risk of NB, using data from the SETIL database.SETIL is a large Italian population-based case-control study established to evaluate several potential cancer risk factors in 0-10 year olds. Information about maternal characteristics, reproductive history, environmental and occupational exposures during pregnancy, as well as newborns' characteristics were obtained using a structured questionnaire. Extremely low frequency magnetic field (ELF-MF) home exposure was measured. The study included 1044 healthy controls and 153 NB cases, diagnosed between 1998 and 2001.A twofold risk was associated to exposure in pregnancy to chemical products for domestic work and to hair dye. The risk associated with the latter was higher among 0-17 month old children (OR=5.5, 95\%CI: 1.0-29.3). Risk was increased for children whose mothers had suffered work related exposure in the preconception period to solvents (OR=2.0 95\%CI: 1.0-4.1) and in particular to aromatic hydrocarbons (OR=9.2, 95\%CI: 2.4-34.3). No association was observed with ELF-MF exposure. A higher risk was found among children with congenital malformations (OR=4.9, 95\%CI: 1.8-13.6) or neurofibromatosis (2 cases and 0 controls, p=0.016).Our study suggests maternal exposure to hair dyes and aromatic hydrocarbons plays a role and deserves further investigation. The association with congenital malformations might also be explained by over-diagnosis. External exposure, in particular during and before pregnancy might contribute to NB occurrence.

AB - Neuroblastoma (NB) is the most common extra-cranial paediatric solid tumour. Incidence peaks in infancy, suggesting a role of in-utero and neonatal exposures but its aetiology is largely unknown. The aim of the present study is to evaluate the association between maternal characteristics and perinatal factors with the risk of NB, using data from the SETIL database.SETIL is a large Italian population-based case-control study established to evaluate several potential cancer risk factors in 0-10 year olds. Information about maternal characteristics, reproductive history, environmental and occupational exposures during pregnancy, as well as newborns' characteristics were obtained using a structured questionnaire. Extremely low frequency magnetic field (ELF-MF) home exposure was measured. The study included 1044 healthy controls and 153 NB cases, diagnosed between 1998 and 2001.A twofold risk was associated to exposure in pregnancy to chemical products for domestic work and to hair dye. The risk associated with the latter was higher among 0-17 month old children (OR=5.5, 95\%CI: 1.0-29.3). Risk was increased for children whose mothers had suffered work related exposure in the preconception period to solvents (OR=2.0 95\%CI: 1.0-4.1) and in particular to aromatic hydrocarbons (OR=9.2, 95\%CI: 2.4-34.3). No association was observed with ELF-MF exposure. A higher risk was found among children with congenital malformations (OR=4.9, 95\%CI: 1.8-13.6) or neurofibromatosis (2 cases and 0 controls, p=0.016).Our study suggests maternal exposure to hair dyes and aromatic hydrocarbons plays a role and deserves further investigation. The association with congenital malformations might also be explained by over-diagnosis. External exposure, in particular during and before pregnancy might contribute to NB occurrence.

UR - https://iris.uniupo.it/handle/11579/56792

U2 - 10.1016/j.canep.2014.09.007

DO - 10.1016/j.canep.2014.09.007

M3 - Article

SN - 1877-7821

VL - 38

SP - 686

EP - 694

JO - Cancer Epidemiology

JF - Cancer Epidemiology

IS - 6

ER -

Risk of neuroblastoma, maternal characteristics and perinatal exposures: The SETIL study.

Abstract

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