Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses?

Alice Trentalange; Enrica Borgogno; Ilaria Motta; Miriam Antonucci; Veronica Pirriatore; Cecilia Costa; Giovanni Rossi; Ambra Barco; Amedeo De Nicolò; Pavilio Piccioni; Antonio D'Avolio; Stefano Bonora; Giovanni Di Perri; Andrea CALCAGNO

doi:10.1016/j.ijantimicag.2021.106297

Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses?

Alice Trentalange
, Enrica Borgogno
, Ilaria Motta
, Miriam Antonucci
, Veronica Pirriatore
, Cecilia Costa
, Giovanni Rossi
, Ambra Barco
, Amedeo De Nicolò
, Pavilio Piccioni
, Antonio D'Avolio
, Stefano Bonora
, Giovanni Di Perri
, Andrea CALCAGNO

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The treatment of drug-sensitive tuberculosis has high effectiveness, yet many patients have suboptimal drugs exposure, possibly explaining treatment failures and selection of resistance. The aim of this study was to describe the prevalence and determinants of antitubercular drugs suboptimal Cmax. METHODS: An observational study was conducted in patients receiving first-line anti-tubercular treatment. At two early time points (T1 and T2) blood samples were withdrawn 2 hours post-dose (maximal concentration, Cmax) and drug concentrations measured. Data are expressed as medians (interquartile ranges).

Lingua originale	Inglese
pagine (da-a)	106297-106297
Numero di pagine	6
Rivista	International Journal of Antimicrobial Agents
Volume	57
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/j.ijantimicag.2021.106297
Stato di pubblicazione	Pubblicato - 2021

Keywords

antitubercular drugs
pharmacokinetics
therapeutic drug monitoring

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Accesso al documento

10.1016/j.ijantimicag.2021.106297

https://hdl.handle.net/11579/216990

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Trentalange, A., Borgogno, E., Motta, I., Antonucci, M., Pirriatore, V., Costa, C., Rossi, G., Barco, A., De Nicolò, A., Piccioni, P., D'Avolio, A., Bonora, S., Perri, G. D., & CALCAGNO, A. (2021). Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses? International Journal of Antimicrobial Agents, 57(3), 106297-106297. https://doi.org/10.1016/j.ijantimicag.2021.106297

@article{c62e27dc1dc04b23b973a9c99061173a,

title = "Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses?",

abstract = "The treatment of drug-sensitive tuberculosis has high effectiveness, yet many patients have suboptimal drugs exposure, possibly explaining treatment failures and selection of resistance. The aim of this study was to describe the prevalence and determinants of antitubercular drugs suboptimal Cmax. METHODS: An observational study was conducted in patients receiving first-line anti-tubercular treatment. At two early time points (T1 and T2) blood samples were withdrawn 2 hours post-dose (maximal concentration, Cmax) and drug concentrations measured. Data are expressed as medians (interquartile ranges).",

keywords = "antitubercular drugs, pharmacokinetics, therapeutic drug monitoring, antitubercular drugs, pharmacokinetics, therapeutic drug monitoring",

author = "Alice Trentalange and Enrica Borgogno and Ilaria Motta and Miriam Antonucci and Veronica Pirriatore and Cecilia Costa and Giovanni Rossi and Ambra Barco and \{De Nicol{\`o}\}, Amedeo and Pavilio Piccioni and Antonio D'Avolio and Stefano Bonora and Perri, \{Giovanni Di\} and Andrea CALCAGNO",

year = "2021",

doi = "10.1016/j.ijantimicag.2021.106297",

language = "English",

volume = "57",

pages = "106297--106297",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

publisher = "Elsevier B.V.",

number = "3",

}

Trentalange, A, Borgogno, E, Motta, I, Antonucci, M, Pirriatore, V, Costa, C, Rossi, G, Barco, A, De Nicolò, A, Piccioni, P, D'Avolio, A, Bonora, S, Perri, GD & CALCAGNO, A 2021, 'Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses?', International Journal of Antimicrobial Agents, vol. 57, n. 3, pagg. 106297-106297. https://doi.org/10.1016/j.ijantimicag.2021.106297

Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses? / Trentalange, Alice; Borgogno, Enrica; Motta, Ilaria et al.
In: International Journal of Antimicrobial Agents, Vol. 57, N. 3, 2021, pag. 106297-106297.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review