TY - JOUR
T1 - Ridge Preservation Using a Novel Freeze-dried Enzymedeantigenic Bone Paste
T2 - A Histomorphometric-retrospective Pilot Case Series
AU - Salmaso, Andrea
AU - Canciani, Elena
AU - Graziano, Daniele
AU - Dellavia, Claudia
N1 - Publisher Copyright:
© 2020 © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons. org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
PY - 2020/9
Y1 - 2020/9
N2 - Aim and objective: The aim of this study is to provide preliminary retrospective evidence concerning the histologic and histomorphometric outcome of a novel freeze-dried equine-derived bone paste (EDEBEX) for ridge preservation of sockets following tooth extraction. Materials and methods: This pilot retrospective case series describes the histologic and histomorphometric outcome of three patients who received the equine-derived bone paste in post-extractive sockets to allow the preservation of the alveolar ridge. Patients were later rehabilitated with monolithic-zirconia, implant-supported prostheses. Results: All patients healed uneventfully. The collected biopsies showed a prevalence of bone formation at 4 months, compact lamellar bone, with well-defined lamellae surrounding Haversian and Volkmann's canals at 6 months, and an intermediate degree of maturation in active anabolic phase at 7 months after grafting. The amount of mineralized matrix was 63.3–70.7%, whereas medullar spaces were 26.0–30.7%. Conclusion: Histologic examination showed that the bone paste was fully biocompatible. Bone regeneration occurred within the first 4 months from grafting, with 63.3–70.7% mineralized bone matrix. The residual biomaterial, when present, did not exceed, on average, 2%. Clinical significance: Ridge preservation using bone substitutes as an alternative to autogenous bone is known to be effective. However, available clinical evidence still does not indicate the biomaterial, if any, that should be preferred to carry it out. The equine bone paste used in the present study appears to be a good candidate for further investigation because it is easy to handle in the clinical setting and it displays a good bone formation rate.
AB - Aim and objective: The aim of this study is to provide preliminary retrospective evidence concerning the histologic and histomorphometric outcome of a novel freeze-dried equine-derived bone paste (EDEBEX) for ridge preservation of sockets following tooth extraction. Materials and methods: This pilot retrospective case series describes the histologic and histomorphometric outcome of three patients who received the equine-derived bone paste in post-extractive sockets to allow the preservation of the alveolar ridge. Patients were later rehabilitated with monolithic-zirconia, implant-supported prostheses. Results: All patients healed uneventfully. The collected biopsies showed a prevalence of bone formation at 4 months, compact lamellar bone, with well-defined lamellae surrounding Haversian and Volkmann's canals at 6 months, and an intermediate degree of maturation in active anabolic phase at 7 months after grafting. The amount of mineralized matrix was 63.3–70.7%, whereas medullar spaces were 26.0–30.7%. Conclusion: Histologic examination showed that the bone paste was fully biocompatible. Bone regeneration occurred within the first 4 months from grafting, with 63.3–70.7% mineralized bone matrix. The residual biomaterial, when present, did not exceed, on average, 2%. Clinical significance: Ridge preservation using bone substitutes as an alternative to autogenous bone is known to be effective. However, available clinical evidence still does not indicate the biomaterial, if any, that should be preferred to carry it out. The equine bone paste used in the present study appears to be a good candidate for further investigation because it is easy to handle in the clinical setting and it displays a good bone formation rate.
KW - Bone formation
KW - Equine bone substitutes
KW - Freeze-dried bone paste
KW - Post-extractive sockets
KW - Ridge preservation
KW - Three-dimensional collagen matrix
KW - Xenograft.
UR - http://www.scopus.com/inward/record.url?scp=85096775594&partnerID=8YFLogxK
U2 - 10.5005/jp-journals-10024-2925
DO - 10.5005/jp-journals-10024-2925
M3 - Article
SN - 1526-3711
VL - 21
SP - 1059
EP - 1067
JO - Journal of Contemporary Dental Practice
JF - Journal of Contemporary Dental Practice
IS - 9
ER -