TY - JOUR
T1 - Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women
T2 - Results from the EPIC Cohort
AU - Sarink, Danja
AU - Yang, Jiaxi
AU - Johnson, Theron
AU - Chang-Claude, Jenny
AU - Overvad, Kim
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Fournier, Agnès
AU - Mancini, Francesca Romana
AU - Kvaskoff, Marina
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - Valanou, Elissavet
AU - Agnoli, Claudia
AU - Sacerdote, Carlotta
AU - Masala, Giovanna
AU - Mattiello, Amalia
AU - Tumino, Rosario
AU - Van Gils, Carla H.
AU - Skeie, Guri
AU - Gram, Inger Torhild
AU - Weiderpass, Elisabete
AU - Lujan-Barroso, Leila
AU - Petrova, Dafina
AU - Santiuste, Carmen
AU - Quirós, J. Ramón
AU - Barricarte, Aurelio
AU - Amiano, Pilar
AU - Travis, Ruth C.
AU - Gunter, Marc
AU - Dossus, Laure
AU - Christakoudi, Sofia
AU - Kaaks, Rudolf
AU - Fortner, Renée Turzanski
N1 - Publisher Copyright:
© 2019 American Association for Cancer Research.
PY - 2019
Y1 - 2019
N2 - Background: Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator of Nuclear Factor kB (sRANKL) and OPG concentrations in women are limited. We evaluated reproductive and lifestyle factors as potential sources of variation in circulating sRANKL and OPG concentrations in pre- and postmenopausal women. Methods: This study includes 2,016 controls [n = 1,552 (76%) postmenopausal, n = 757 (38%) using postmenopausal hormone therapy (PMH)] from a breast cancer case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Serum sRANKL was measured using an ELISA and serum OPG using an electrochemiluminescent assay. Generalized linear models were used to evaluate associations between these analytes and reproductive and lifestyle factors. Results: Older age at blood collection was associated with lower sRANKL concentrations in postmenopausal women (Ptrend < 0.03) and higher OPG concentrations in all women (Ptrend < 0.01). Longer duration of oral contraceptive use among premenopausal women and postmenopausal PMH users was associated with higher OPG (Ptrend < 0.04). In postmenopausal non-PMH users, sRANKL concentrations were lower with longer duration of oral contraceptive use and current (vs. never) smoking (P < 0.01). sRANKL concentrations were higher among women with higher BMI (Ptrend < 0.01). The evaluated factors accounted for 12% of the variation in sRANKL concentrations and 21% of the variation in OPG concentrations. Conclusions: Circulating sRANKL and OPG concentrations are minimally impacted by hormone-related factors in pre- and postmenopausal women. Impact: This study suggests circulating concentrations of sRANKL and OPG are unlikely to be strongly modified by hormone-related reproductive and lifestyle factors.
AB - Background: Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator of Nuclear Factor kB (sRANKL) and OPG concentrations in women are limited. We evaluated reproductive and lifestyle factors as potential sources of variation in circulating sRANKL and OPG concentrations in pre- and postmenopausal women. Methods: This study includes 2,016 controls [n = 1,552 (76%) postmenopausal, n = 757 (38%) using postmenopausal hormone therapy (PMH)] from a breast cancer case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Serum sRANKL was measured using an ELISA and serum OPG using an electrochemiluminescent assay. Generalized linear models were used to evaluate associations between these analytes and reproductive and lifestyle factors. Results: Older age at blood collection was associated with lower sRANKL concentrations in postmenopausal women (Ptrend < 0.03) and higher OPG concentrations in all women (Ptrend < 0.01). Longer duration of oral contraceptive use among premenopausal women and postmenopausal PMH users was associated with higher OPG (Ptrend < 0.04). In postmenopausal non-PMH users, sRANKL concentrations were lower with longer duration of oral contraceptive use and current (vs. never) smoking (P < 0.01). sRANKL concentrations were higher among women with higher BMI (Ptrend < 0.01). The evaluated factors accounted for 12% of the variation in sRANKL concentrations and 21% of the variation in OPG concentrations. Conclusions: Circulating sRANKL and OPG concentrations are minimally impacted by hormone-related factors in pre- and postmenopausal women. Impact: This study suggests circulating concentrations of sRANKL and OPG are unlikely to be strongly modified by hormone-related reproductive and lifestyle factors.
UR - http://www.scopus.com/inward/record.url?scp=85072849223&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-19-0241
DO - 10.1158/1055-9965.EPI-19-0241
M3 - Article
SN - 1055-9965
VL - 28
SP - 1746
EP - 1754
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 10
ER -
