Remifentanil effects on respiratory drive and timing during pressure support ventilation and neurally adjusted ventilatory assist

We assessed the effects of varying doses of remifentanil on respiratory drive and timing in patients receiving Pressure Support Ventilation (PSV) and Neurally Adjusted Ventilatory Assist (NAVA). Four incrementing remifentanil doses were randomly administered to thirteen intubated patients (0.03, 0.05, 0.08, and 0.1μg·Kg⁻¹·min⁻1) during both PSV and NAVA. We measured the patient's (Ti/Ttot_neu) and ventilator (Ti/Ttot_mec) duty cycle, the Electrical Activity of the Diaphragm (EAdi), the inspiratory (Delay_trinsp) and expiratory (Delay_trexp) trigger delays and the Asynchrony Index (AI). Increasing doses of remifentanil did not modify EAdi, regardless the ventilatory mode. In comparison to baseline, remifentanil infusion >0.05μg/Kg⁻¹/min⁻¹ produced a significant reduction of Ti/Ttot_neu and Ti/Ttot_mec by prolonging the expiratory time. Delay_trinsp and Delay_trexp were significantly shorter in NAVA, respect to PSV. AI was not influenced by the different doses of remifentanil, but it was significantly lower during NAVA, compared to PSV. In conclusion remifentanil did not affect the respiratory drive, but only respiratory timing, without differences between modes.