Relaxivity Enhancement of Ditopic Bishydrated Gadolinium(III) Complexes Conjugated to Mesoporous Silica Nanoparticles

Fabio Carniato, Lorenzo Tei, Jonathan Martinelli, Mauro Botta

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Dinuclear Gd3+ complexes containing thermodynamically stable and bishydrated GdAAZTA (AAZTA = 6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) chelates were covalently linked to the surfaces of mesoporous silica nanoparticles and decorated with poly(ethylene glycol) (PEG5000) molecules. The surface and textural properties of the samples were analyzed. A detailed 1H NMR relaxometric characterization as a function of the applied magnetic-field strength was performed for the conjugated systems in aqueous solutions to evaluate their efficacy as potential magnetic resonance imaging (MRI) diagnostic probes. The samples showed enhanced longitudinal relaxivity values (37.5 mm–1 s–1 per ion at 0.7 T and 310 K) compared with those of the free complex (+270 %) and related nanosystems based on monohydrated Gd3+ chelates (+42 %). The relaxivity gain is the result of the rational design of the ditopic complex, as it ensures an increased hydration state (q = 2), improvement of the rotational dynamics and a fast rate of water exchange between the inner coordination sphere and the bulk. These favourable properties are obtained without compromise to the high thermodynamic stability and kinetic inertness of the chelating units.

Lingua originaleInglese
pagine (da-a)2363-2368
Numero di pagine6
RivistaEuropean Journal of Inorganic Chemistry
Volume2018
Numero di pubblicazione20
DOI
Stato di pubblicazionePubblicato - 7 giu 2018

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