TY - JOUR
T1 - Relative survival of patients with lupus nephritis significantly improved over time in an Italian region
T2 - comment on the article by Faurschou et al.
AU - Stratta, Piero
AU - Canavese, Caterina
AU - Ciccone, Giovannino
AU - Rosso, Stefano
PY - 2010/12
Y1 - 2010/12
N2 - Immunosuppressive treatment has changed the prognosis of Lupus nephritis over time, but improvement in
prognosis is difficult to analyze in different historical periods, and should be better demonstrated in comparison
with life expectancy of sex-and age-matched people. Long-term patient and renal survival of 90 patients
diagnosed with Lupus nephritis at our center from 1968 to 2001 with a follow-up time of 14±8 years was
retrospectively evaluated. Patient and kidney survival significantly increased over time. Multivariate analyses
show that risks of patient and renal death decreased by 8% at each year of follow-up, and increased by more than
5 time in patients aged > 30 years at diagnosis. As only 14 patients were men, relative survival as compared to that
of the sex- and age-matched general population of the Piedmont Region was calculated for the 76 women.
Improvement in the survival of the cohort of women was seen at any time of follow-up: in particular, it was
sharply lower in the first period (relative survival at 5, 10 and 15 years = 0.784, 0.665, and 0.620, respectively) and
increased in the second (relative survival at 5, 10 and 15 years = 0.939, 0.921, and 0.850, respectively) nearly
approaching that expected for the general population, i.e. 0.993, 0.983 and 0.967, respectively. Taken together,
our data allow us to draw the conclusion that life expectancy in women with Lupus nephritis has improved over
time, paralleling an improved awareness of the disease and a significant increase in steroid pulse therapy as
induction/remission phase. Improvement in survival is for the first time demonstrated to cover the gap with life
expectancy of the general population for women with Lupus nephritis.
AB - Immunosuppressive treatment has changed the prognosis of Lupus nephritis over time, but improvement in
prognosis is difficult to analyze in different historical periods, and should be better demonstrated in comparison
with life expectancy of sex-and age-matched people. Long-term patient and renal survival of 90 patients
diagnosed with Lupus nephritis at our center from 1968 to 2001 with a follow-up time of 14±8 years was
retrospectively evaluated. Patient and kidney survival significantly increased over time. Multivariate analyses
show that risks of patient and renal death decreased by 8% at each year of follow-up, and increased by more than
5 time in patients aged > 30 years at diagnosis. As only 14 patients were men, relative survival as compared to that
of the sex- and age-matched general population of the Piedmont Region was calculated for the 76 women.
Improvement in the survival of the cohort of women was seen at any time of follow-up: in particular, it was
sharply lower in the first period (relative survival at 5, 10 and 15 years = 0.784, 0.665, and 0.620, respectively) and
increased in the second (relative survival at 5, 10 and 15 years = 0.939, 0.921, and 0.850, respectively) nearly
approaching that expected for the general population, i.e. 0.993, 0.983 and 0.967, respectively. Taken together,
our data allow us to draw the conclusion that life expectancy in women with Lupus nephritis has improved over
time, paralleling an improved awareness of the disease and a significant increase in steroid pulse therapy as
induction/remission phase. Improvement in survival is for the first time demonstrated to cover the gap with life
expectancy of the general population for women with Lupus nephritis.
UR - http://www.scopus.com/inward/record.url?scp=79952116005&partnerID=8YFLogxK
U2 - 10.1002/acr.20296
DO - 10.1002/acr.20296
M3 - Comment/debate
SN - 2151-464X
VL - 62
SP - 1812-1813; author reply 1813
JO - Arthritis Care and Research
JF - Arthritis Care and Research
IS - 12
ER -