Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides

Barbara La Ferla, Luigi Lay, Giovanni Russo, Luigi Panza

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Supported lipase from Candida antarctica (Chirazyme®) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of β-D-Gal(1→3)-D-GlcNAc and β-D-Gal(1→4)-D-GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. Copyright (C) 2000 Elsevier Science Ltd.

Lingua originaleInglese
pagine (da-a)3647-3651
Numero di pagine5
RivistaTetrahedron Asymmetry
Volume11
Numero di pubblicazione18
DOI
Stato di pubblicazionePubblicato - 22 set 2000

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