TY - JOUR
T1 - Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides
AU - La Ferla, Barbara
AU - Lay, Luigi
AU - Russo, Giovanni
AU - Panza, Luigi
N1 - Funding Information:
This work was supported by EU-NOFA project (grant FAIR CT973142).
PY - 2000/9/22
Y1 - 2000/9/22
N2 - Supported lipase from Candida antarctica (Chirazyme®) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of β-D-Gal(1→3)-D-GlcNAc and β-D-Gal(1→4)-D-GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. Copyright (C) 2000 Elsevier Science Ltd.
AB - Supported lipase from Candida antarctica (Chirazyme®) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of β-D-Gal(1→3)-D-GlcNAc and β-D-Gal(1→4)-D-GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. Copyright (C) 2000 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0034703148&partnerID=8YFLogxK
U2 - 10.1016/S0957-4166(00)00342-6
DO - 10.1016/S0957-4166(00)00342-6
M3 - Article
SN - 0957-4166
VL - 11
SP - 3647
EP - 3651
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 18
ER -