Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis

Eva Åkesson; Francesca Coraddu; Maria Giovanna Marrosu; Luca Massacesi; Anke Hensiek; Hanne Flinstad Harbo; Annette Oturai; Maria Trojano; Patricia Momigliano-Richiardi; Eleonora Cocco; Raffaele Murru; Jan Hillert; Alastair Compston; Stephen Sawcer

doi:10.1016/j.jneuroim.2003.08.008

Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis

Eva Åkesson, Francesca Coraddu, Maria Giovanna Marrosu, Luca Massacesi, Anke Hensiek, Hanne Flinstad Harbo, Annette Oturai, Maria Trojano, Patricia Momigliano-Richiardi, Eleonora Cocco, Raffaele Murru, Jan Hillert, Alastair Compston, Stephen Sawcer

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Genome-wide screens for linkage in multiplex families with multiple sclerosis (MS) from United Kingdom, Sardinia, Italy and the Nordic countries (Denmark, Finland, Norway and Sweden) have each shown suggestive or potential linkage on chromosome 10. The partially overlapping regions identified by these studies encompass around 60 cM of the chromosome. In order to explore this region further, we typed 13 microsatellite markers in the same 449 families originally studied in the individual screens. This additional genotyping increased the information extraction in the region from 52% to 79% and revealed increased support for linkage (MLS 2.5) peaking at 10p15.

Lingua originale	Inglese
pagine (da-a)	31-38
Numero di pagine	8
Rivista	Journal of Neuroimmunology
Volume	143
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/j.jneuroim.2003.08.008
Stato di pubblicazione	Pubblicato - ott 2003
Pubblicato esternamente	Sì

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Åkesson, E., Coraddu, F., Marrosu, M. G., Massacesi, L., Hensiek, A., Harbo, H. F., Oturai, A., Trojano, M., Momigliano-Richiardi, P., Cocco, E., Murru, R., Hillert, J., Compston, A., & Sawcer, S. (2003). Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis. Journal of Neuroimmunology, 143(1-2), 31-38. https://doi.org/10.1016/j.jneuroim.2003.08.008

@article{b45565f6c81b4babaad66ee44f13f4ff,

title = "Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis",

abstract = "Genome-wide screens for linkage in multiplex families with multiple sclerosis (MS) from United Kingdom, Sardinia, Italy and the Nordic countries (Denmark, Finland, Norway and Sweden) have each shown suggestive or potential linkage on chromosome 10. The partially overlapping regions identified by these studies encompass around 60 cM of the chromosome. In order to explore this region further, we typed 13 microsatellite markers in the same 449 families originally studied in the individual screens. This additional genotyping increased the information extraction in the region from 52% to 79% and revealed increased support for linkage (MLS 2.5) peaking at 10p15.",

keywords = "Linkage, Map density, Multiple sclerosis, Susceptibility gene",

author = "Eva {\AA}kesson and Francesca Coraddu and Marrosu, {Maria Giovanna} and Luca Massacesi and Anke Hensiek and Harbo, {Hanne Flinstad} and Annette Oturai and Maria Trojano and Patricia Momigliano-Richiardi and Eleonora Cocco and Raffaele Murru and Jan Hillert and Alastair Compston and Stephen Sawcer",

note = "Funding Information: We are grateful to neurologists from the contributing countries who identified the families involved in this study. This work was supported by the Wellcome Trust (grant 057097), the Multiple Sclerosis Society of Great Britain and Northern Ireland (grant 591/00), the European Commission (project number CT97-2422), the Danish Multiple Sclerosis Society, the Italian Foundation for Multiple Sclerosis (FISM), the Swedish Medical Research Council (project number: 11220), the Swedish Association of Neurologically Disabled and Karolinska Institute. We thank J. Gray, B. Smillie and M. Maranian for the expert technical assistance.",

year = "2003",

month = oct,

doi = "10.1016/j.jneuroim.2003.08.008",

language = "English",

volume = "143",

pages = "31--38",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

number = "1-2",

}

Åkesson, E, Coraddu, F, Marrosu, MG, Massacesi, L, Hensiek, A, Harbo, HF, Oturai, A, Trojano, M, Momigliano-Richiardi, P, Cocco, E, Murru, R, Hillert, J, Compston, A & Sawcer, S 2003, 'Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis', Journal of Neuroimmunology, vol. 143, n. 1-2, pagg. 31-38. https://doi.org/10.1016/j.jneuroim.2003.08.008

TY - JOUR

T1 - Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis

AU - Åkesson, Eva

AU - Coraddu, Francesca

AU - Marrosu, Maria Giovanna

AU - Massacesi, Luca

AU - Hensiek, Anke

AU - Harbo, Hanne Flinstad

AU - Oturai, Annette

AU - Trojano, Maria

AU - Momigliano-Richiardi, Patricia

AU - Cocco, Eleonora

AU - Murru, Raffaele

AU - Hillert, Jan

AU - Compston, Alastair

AU - Sawcer, Stephen

N1 - Funding Information: We are grateful to neurologists from the contributing countries who identified the families involved in this study. This work was supported by the Wellcome Trust (grant 057097), the Multiple Sclerosis Society of Great Britain and Northern Ireland (grant 591/00), the European Commission (project number CT97-2422), the Danish Multiple Sclerosis Society, the Italian Foundation for Multiple Sclerosis (FISM), the Swedish Medical Research Council (project number: 11220), the Swedish Association of Neurologically Disabled and Karolinska Institute. We thank J. Gray, B. Smillie and M. Maranian for the expert technical assistance.

PY - 2003/10

Y1 - 2003/10

N2 - Genome-wide screens for linkage in multiplex families with multiple sclerosis (MS) from United Kingdom, Sardinia, Italy and the Nordic countries (Denmark, Finland, Norway and Sweden) have each shown suggestive or potential linkage on chromosome 10. The partially overlapping regions identified by these studies encompass around 60 cM of the chromosome. In order to explore this region further, we typed 13 microsatellite markers in the same 449 families originally studied in the individual screens. This additional genotyping increased the information extraction in the region from 52% to 79% and revealed increased support for linkage (MLS 2.5) peaking at 10p15.

AB - Genome-wide screens for linkage in multiplex families with multiple sclerosis (MS) from United Kingdom, Sardinia, Italy and the Nordic countries (Denmark, Finland, Norway and Sweden) have each shown suggestive or potential linkage on chromosome 10. The partially overlapping regions identified by these studies encompass around 60 cM of the chromosome. In order to explore this region further, we typed 13 microsatellite markers in the same 449 families originally studied in the individual screens. This additional genotyping increased the information extraction in the region from 52% to 79% and revealed increased support for linkage (MLS 2.5) peaking at 10p15.

KW - Linkage

KW - Map density

KW - Multiple sclerosis

KW - Susceptibility gene

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U2 - 10.1016/j.jneuroim.2003.08.008

DO - 10.1016/j.jneuroim.2003.08.008

M3 - Article

SN - 0165-5728

VL - 143

SP - 31

EP - 38

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis

Abstract

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