TY - JOUR
T1 - Redefining residual inflammatory risk after acute coronary syndrome
AU - Del Buono, Marco G
AU - Montone, Rocco A
AU - Iannaccone, Giulia
AU - Rinaldi, Riccardo
AU - La Vecchia, Giulia
AU - Camilli, Massimiliano
AU - Gurgoglione, Filippo L
AU - Russo, Michele
AU - Lombardi, Marco
AU - D'AMARIO, DOMENICO
AU - Niccoli, Giampaolo
PY - 2022
Y1 - 2022
N2 - Over the last decades, inflammation proved to play a pivotal role in atherosclerotic plaque formation, progression and destabilization. Several studies showed that the patients presenting with acute coronary syndrome are at increased risk of adverse cardiovascular events at both short- and long-term follow-up. Results from different clinical trials highlighted that a residual inflammatory risk exist and targeting inflammation is a successful strategy in selected cases associated to an increased inflammatory burden. Recently, the optimization of intracoronary and multimodality imaging allowed to also assess the entity of local inflammation, thus encouraging the individuation of plaque characteristics that portend a higher risk of future cardiovascular events. In this short review, we aim to highlight the role of systemic and local inflammation in acute coronary syndromes, to provide a summarized overview of the possible medical strategies applicable in selected cases and to underline the diagnostic and prognostic potential of multimodality imaging.
AB - Over the last decades, inflammation proved to play a pivotal role in atherosclerotic plaque formation, progression and destabilization. Several studies showed that the patients presenting with acute coronary syndrome are at increased risk of adverse cardiovascular events at both short- and long-term follow-up. Results from different clinical trials highlighted that a residual inflammatory risk exist and targeting inflammation is a successful strategy in selected cases associated to an increased inflammatory burden. Recently, the optimization of intracoronary and multimodality imaging allowed to also assess the entity of local inflammation, thus encouraging the individuation of plaque characteristics that portend a higher risk of future cardiovascular events. In this short review, we aim to highlight the role of systemic and local inflammation in acute coronary syndromes, to provide a summarized overview of the possible medical strategies applicable in selected cases and to underline the diagnostic and prognostic potential of multimodality imaging.
KW - acute coronary syndromes
KW - percutaneous coronary interventions
KW - personalized medicine
KW - acute coronary syndromes
KW - percutaneous coronary interventions
KW - personalized medicine
UR - https://iris.uniupo.it/handle/11579/176202
U2 - 10.2217/fca-2021-0032
DO - 10.2217/fca-2021-0032
M3 - Literature review
SN - 1744-8298
VL - 18
JO - FUTURE CARDIOLOGY
JF - FUTURE CARDIOLOGY
IS - 2
ER -