Reconstituted extracellular matrix improve osteoblastic differentiation onto titanium surfaces

Lia Rimondini, Federica Demarosi, Ismaela Foltran, Nadia Quirici

Risultato della ricerca: Capitolo in libro/report/atti di convegnoContributo a conferenzapeer review

Abstract

Electrospinning technique is an efficient processing method to manufacture micro- and nano-sized fibrous structures by electrostatic force for different applications. In biomaterial field, electrospinning technique has been successfully utilized to prepare new drug delivery materials and tissue engineering scaffolds. Fiber mats of biodegradable polymers having a diameter in the nano- to submicro-scale can be considered to mimic the nanofibrous structure of native extracellular matrix (ECM). Native extracellular matrix, constituted of proteins and polysaccharides improving cells growth in its nanofibrous porous structure, controls not only the cell phenotype, but the whole structure of the biological tissues. In the present study we investigated the effect of electrospun reconstituted collagen fibers onto metals for oral implants devices manufacturing as far as the osteoblastic differentiation potential of stem cells and cytofunctionality of osteoblasts in-vitro. The cells cultured onto titanium samples coated with ECM constituents showed faster osteoblastic differentiation and more efficient deposition of mineralized matrix in comparison with those onto uncoated substrates.

Lingua originaleInglese
Titolo della pubblicazione ospiteTHERMEC 2011
EditoreTrans Tech Publications Ltd
Pagine584-588
Numero di pagine5
ISBN (stampa)9783037853030
DOI
Stato di pubblicazionePubblicato - 2012
Evento7th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC'2011 - Quebec City, QC, Canada
Durata: 1 ago 20115 ago 2011

Serie di pubblicazioni

NomeMaterials Science Forum
Volume706-709
ISSN (stampa)0255-5476
ISSN (elettronico)1662-9752

???event.eventtypes.event.conference???

???event.eventtypes.event.conference???7th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC'2011
Paese/TerritorioCanada
CittàQuebec City, QC
Periodo1/08/115/08/11

Fingerprint

Entra nei temi di ricerca di 'Reconstituted extracellular matrix improve osteoblastic differentiation onto titanium surfaces'. Insieme formano una fingerprint unica.

Cita questo