Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte; Sven Brandau; Shu Hsia Chen; Mario P. Colombo; Alan B. Frey; Tim F. Greten; Susanna Mandruzzato; Peter J. Murray; Augusto Ochoa; Suzanne Ostrand-Rosenberg; Paulo C. Rodriguez; Antonio Sica; Viktor Umansky; Robert H. Vonderheide; Dmitry I. Gabrilovich

doi:10.1038/ncomms12150

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte, Sven Brandau, Shu Hsia Chen, Mario P. Colombo, Alan B. Frey, Tim F. Greten, Susanna Mandruzzato, Peter J. Murray, Augusto Ochoa, Suzanne Ostrand-Rosenberg, Paulo C. Rodriguez, Antonio Sica, Viktor Umansky, Robert H. Vonderheide, Dmitry I. Gabrilovich

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

Lingua originale	Inglese
Numero di articolo	12150
Rivista	Nature Communications
Volume	7
DOI	https://doi.org/10.1038/ncomms12150
Stato di pubblicazione	Pubblicato - 6 lug 2016

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10.1038/ncomms12150

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Bronte, V., Brandau, S., Chen, S. H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., Rodriguez, P. C., Sica, A., Umansky, V., Vonderheide, R. H., & Gabrilovich, D. I. (2016). Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nature Communications, 7, Articolo 12150. https://doi.org/10.1038/ncomms12150

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title = "Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards",

abstract = "Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.",

author = "Vincenzo Bronte and Sven Brandau and Chen, {Shu Hsia} and Colombo, {Mario P.} and Frey, {Alan B.} and Greten, {Tim F.} and Susanna Mandruzzato and Murray, {Peter J.} and Augusto Ochoa and Suzanne Ostrand-Rosenberg and Rodriguez, {Paulo C.} and Antonio Sica and Viktor Umansky and Vonderheide, {Robert H.} and Gabrilovich, {Dmitry I.}",

year = "2016",

month = jul,

day = "6",

doi = "10.1038/ncomms12150",

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Bronte, V, Brandau, S, Chen, SH, Colombo, MP, Frey, AB, Greten, TF, Mandruzzato, S, Murray, PJ, Ochoa, A, Ostrand-Rosenberg, S, Rodriguez, PC, Sica, A, Umansky, V, Vonderheide, RH & Gabrilovich, DI 2016, 'Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards', Nature Communications, vol. 7, 12150. https://doi.org/10.1038/ncomms12150

TY - JOUR

T1 - Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

AU - Bronte, Vincenzo

AU - Brandau, Sven

AU - Chen, Shu Hsia

AU - Colombo, Mario P.

AU - Frey, Alan B.

AU - Greten, Tim F.

AU - Mandruzzato, Susanna

AU - Murray, Peter J.

AU - Ochoa, Augusto

AU - Ostrand-Rosenberg, Suzanne

AU - Rodriguez, Paulo C.

AU - Sica, Antonio

AU - Umansky, Viktor

AU - Vonderheide, Robert H.

AU - Gabrilovich, Dmitry I.

PY - 2016/7/6

Y1 - 2016/7/6

N2 - Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

AB - Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

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U2 - 10.1038/ncomms12150

DO - 10.1038/ncomms12150

M3 - Review article

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

M1 - 12150

ER -

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Abstract

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