Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain

Ferdinando Nicoletti; Pier Luigi Canonico; Antonella Favit; Giovanni Nicoletti; Vincenzo Albanese

doi:10.1016/0014-2999(89)90504-9

Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain

Ferdinando Nicoletti, Pier Luigi Canonico, Antonella Favit, Giovanni Nicoletti, Vincenzo Albanese

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Stimulation of inositol phospolipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [³H]inositolmonophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.

Lingua originale	Inglese
pagine (da-a)	299-301
Numero di pagine	3
Rivista	European Journal of Pharmacology
Volume	160
Numero di pubblicazione	2
DOI	https://doi.org/10.1016/0014-2999(89)90504-9
Stato di pubblicazione	Pubblicato - 31 gen 1989
Pubblicato esternamente	Sì

Accesso al documento

10.1016/0014-2999(89)90504-9

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{15e24d3c2b78436da7876478d1b4e303,

title = "Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain",

abstract = "Stimulation of inositol phospolipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositolmonophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.",

keywords = "Brain (human), Carbachol, Inositol phospholipids, Norepinephrine, Quisqualate",

author = "Ferdinando Nicoletti and Canonico, {Pier Luigi} and Antonella Favit and Giovanni Nicoletti and Vincenzo Albanese",

year = "1989",

month = jan,

day = "31",

doi = "10.1016/0014-2999(89)90504-9",

language = "English",

volume = "160",

pages = "299--301",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain

AU - Nicoletti, Ferdinando

AU - Canonico, Pier Luigi

AU - Favit, Antonella

AU - Nicoletti, Giovanni

AU - Albanese, Vincenzo

PY - 1989/1/31

Y1 - 1989/1/31

N2 - Stimulation of inositol phospolipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositolmonophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.

AB - Stimulation of inositol phospolipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositolmonophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.

KW - Brain (human)

KW - Carbachol

KW - Inositol phospholipids

KW - Norepinephrine

KW - Quisqualate

UR - http://www.scopus.com/inward/record.url?scp=0024535286&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(89)90504-9

DO - 10.1016/0014-2999(89)90504-9

M3 - Article

SN - 0014-2999

VL - 160

SP - 299

EP - 301

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo