Recent advances in hiv-associated kaposi sarcoma

Alessia Dalla Pria; David J. Pinato; Margherita Bracchi; Mark Bower

doi:10.12688/f1000research.17401.1

Recent advances in hiv-associated kaposi sarcoma

Alessia Dalla Pria, David J. Pinato, Margherita Bracchi, Mark Bower

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Kaposi sarcoma (KS) is a mesenchymal tumour caused by KS-associated herpesvirus and is an AIDS-defining illness. Despite a decline in incidence since the introduction of combination anti-retroviral therapy, KS remains the most common cancer in people living with HIV in sub-Saharan Africa, where it causes significant morbidity and mortality. This review reflects on recent epidemiological data as well as current management, unmet needs and future perspectives in the treatment of HIV-associated KS with particular emphasis on the potential role of immune checkpoint inhibitors.

Lingua originale	Inglese
Numero di articolo	970
Rivista	F1000Research
Volume	8
DOI	https://doi.org/10.12688/f1000research.17401.1
Stato di pubblicazione	Pubblicato - 2019
Pubblicato esternamente	Sì

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title = "Recent advances in hiv-associated kaposi sarcoma",

abstract = "Kaposi sarcoma (KS) is a mesenchymal tumour caused by KS-associated herpesvirus and is an AIDS-defining illness. Despite a decline in incidence since the introduction of combination anti-retroviral therapy, KS remains the most common cancer in people living with HIV in sub-Saharan Africa, where it causes significant morbidity and mortality. This review reflects on recent epidemiological data as well as current management, unmet needs and future perspectives in the treatment of HIV-associated KS with particular emphasis on the potential role of immune checkpoint inhibitors.",

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AU - Pinato, David J.

AU - Bracchi, Margherita

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N2 - Kaposi sarcoma (KS) is a mesenchymal tumour caused by KS-associated herpesvirus and is an AIDS-defining illness. Despite a decline in incidence since the introduction of combination anti-retroviral therapy, KS remains the most common cancer in people living with HIV in sub-Saharan Africa, where it causes significant morbidity and mortality. This review reflects on recent epidemiological data as well as current management, unmet needs and future perspectives in the treatment of HIV-associated KS with particular emphasis on the potential role of immune checkpoint inhibitors.

AB - Kaposi sarcoma (KS) is a mesenchymal tumour caused by KS-associated herpesvirus and is an AIDS-defining illness. Despite a decline in incidence since the introduction of combination anti-retroviral therapy, KS remains the most common cancer in people living with HIV in sub-Saharan Africa, where it causes significant morbidity and mortality. This review reflects on recent epidemiological data as well as current management, unmet needs and future perspectives in the treatment of HIV-associated KS with particular emphasis on the potential role of immune checkpoint inhibitors.

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KW - HIV

KW - KS

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Recent advances in hiv-associated kaposi sarcoma

Abstract

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