TY - JOUR
T1 - Rearrangements and aberrant expression of the retinoic acid receptor α gene in acute promyelocytic leukemias
AU - Longo, Letizia
AU - Pandolfi, Pier Paolo
AU - Biondi, Andrea
AU - Rambaldi, Alessandro
AU - Mencarelli, Amedea
AU - Lo Coco, Francesco
AU - Diverio, Daniela
AU - Pegoraro, Luigi
AU - Avanzi, Giancarlo
AU - Tabilio, Antonio
AU - Zangrilli, Daniela
AU - Alcalay, Myriam
AU - Donti, Emilio
AU - Grignani, Fausto
AU - Pelicci, Pier Giuseppe
PY - 1990/12/1
Y1 - 1990/12/1
N2 - Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor α (RARa) locus. Investigation of 20 APLs and a large series of other neoplastic patients and normal controls revealed RARα gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RARα gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes.
AB - Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor α (RARa) locus. Investigation of 20 APLs and a large series of other neoplastic patients and normal controls revealed RARα gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RARα gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes.
UR - http://www.scopus.com/inward/record.url?scp=0025646509&partnerID=8YFLogxK
M3 - Article
SN - 0022-1007
VL - 172
SP - 1571
EP - 1575
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 6
ER -