Reaction between (Z)-Arylchlorooximes and α-Isocyanoacetamides: A procedure for the synthesis of Aryl-α-ketoamide amides

Mariateresa Giustiniano; Valentina Mercalli; Hilde Cassese; Salvatore Di Maro; Ubaldina Galli; Ettore Novellino; Gian Cesare Tron

doi:10.1021/jo5005444

Reaction between (Z)-Arylchlorooximes and α-Isocyanoacetamides: A procedure for the synthesis of Aryl-α-ketoamide amides

Mariateresa Giustiniano, Valentina Mercalli, Hilde Cassese, Salvatore Di Maro, Ubaldina Galli, Ettore Novellino, Gian Cesare Tron

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

(Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring and deoximation reaction give a facile access to aryl-α-ketoamide amides, a class of privileged scaffolds in medicinal chemistry and important synthetic intermediates in organic chemistry.

Lingua originale	Inglese
pagine (da-a)	6006-6014
Numero di pagine	9
Rivista	Journal of Organic Chemistry
Volume	79
Numero di pubblicazione	13
DOI	https://doi.org/10.1021/jo5005444
Stato di pubblicazione	Pubblicato - 3 lug 2014

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10.1021/jo5005444

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title = "Reaction between (Z)-Arylchlorooximes and α-Isocyanoacetamides: A procedure for the synthesis of Aryl-α-ketoamide amides",

abstract = "(Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring and deoximation reaction give a facile access to aryl-α-ketoamide amides, a class of privileged scaffolds in medicinal chemistry and important synthetic intermediates in organic chemistry.",

author = "Mariateresa Giustiniano and Valentina Mercalli and Hilde Cassese and \{Di Maro\}, Salvatore and Ubaldina Galli and Ettore Novellino and Tron, \{Gian Cesare\}",

year = "2014",

month = jul,

day = "3",

doi = "10.1021/jo5005444",

language = "English",

volume = "79",

pages = "6006--6014",

journal = "Journal of Organic Chemistry",

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T2 - A procedure for the synthesis of Aryl-α-ketoamide amides

AU - Giustiniano, Mariateresa

AU - Mercalli, Valentina

AU - Cassese, Hilde

AU - Di Maro, Salvatore

AU - Galli, Ubaldina

AU - Novellino, Ettore

AU - Tron, Gian Cesare

PY - 2014/7/3

Y1 - 2014/7/3

N2 - (Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring and deoximation reaction give a facile access to aryl-α-ketoamide amides, a class of privileged scaffolds in medicinal chemistry and important synthetic intermediates in organic chemistry.

AB - (Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring and deoximation reaction give a facile access to aryl-α-ketoamide amides, a class of privileged scaffolds in medicinal chemistry and important synthetic intermediates in organic chemistry.

UR - https://www.scopus.com/pages/publications/84903731145

U2 - 10.1021/jo5005444

DO - 10.1021/jo5005444

M3 - Article

SN - 0022-3263

VL - 79

SP - 6006

EP - 6014

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 13

ER -

Reaction between (Z)-Arylchlorooximes and α-Isocyanoacetamides: A procedure for the synthesis of Aryl-α-ketoamide amides

Abstract

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