Rational Design of High-Relaxivity EuII-Based Contrast Agents for Magnetic Resonance Imaging of Low-Oxygen Environments

Matthew D. Bailey, Guo Xia Jin, Fabio Carniato, Mauro Botta, Matthew J. Allen

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Metal-based contrast agents for magnetic resonance imaging present a promising avenue to image hypoxia. EuII-based contrast agents have a unique biologically relevant redox couple, EuII/III, that distinguishes this metal for use in hypoxia imaging. To that end, we investigated a strategy to enhance the contrast-enhancing capabilities of EuII-based cryptates in magnetic resonance imaging by controlling the rotational dynamics. Two dimetallic, EuII-containing cryptates were synthesized to test the efficacy of rigid versus flexible coupling strategies. A flexible strategy to dimerization led to a modest (114 %) increase in contrast enhancement per Eu ion (60 MHz, 298 K), but a rigid linking strategy led to an excellent (186 %) increase in contrast enhancement despite this compound′s having the smaller molecular mass of the two dimetallic complexes. We envision the rigid linking strategy to be useful in the future design of potent EuII-based contrast agents for magnetic resonance imaging.

Lingua originaleInglese
pagine (da-a)3114-3118
Numero di pagine5
RivistaChemistry - A European Journal
Volume27
Numero di pubblicazione9
DOI
Stato di pubblicazionePubblicato - 10 feb 2021

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