Rapid synthesis of triazole-modified resveratrol analogues via click chemistry

Francesca Pagliai; Tracey Pirali; Erika Del Grosso; Riccardo Di Brisco; Gian Cesare Tron; Giovanni Sorba; Armando A. Genazzani

doi:10.1021/jm051118z

Rapid synthesis of triazole-modified resveratrol analogues via click chemistry

Francesca Pagliai, Tracey Pirali, Erika Del Grosso, Riccardo Di Brisco, Gian Cesare Tron, Giovanni Sorba, Armando A. Genazzani

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction: the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency.

Lingua originale	Inglese
pagine (da-a)	467-470
Numero di pagine	4
Rivista	Journal of Medicinal Chemistry
Volume	49
Numero di pubblicazione	2
DOI	https://doi.org/10.1021/jm051118z
Stato di pubblicazione	Pubblicato - 26 gen 2006

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10.1021/jm051118z

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abstract = "Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction: the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency.",

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AU - Tron, Gian Cesare

AU - Sorba, Giovanni

AU - Genazzani, Armando A.

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AB - Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction: the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency.

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Rapid synthesis of triazole-modified resveratrol analogues via click chemistry

Abstract

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