Rai is a New Regulator of Neural Progenitor Migration and Glioblastoma Invasion

B Ortensi; D Osti; S Pellegatta; F Pisati; P Brescia; L Fornasari; D Levi; P Gaetani; P Colombo; A Ferri; S Nicolis; G Finocchiaro; Giuliana PELICCI

doi:10.1002/stem.1056

Rai is a New Regulator of Neural Progenitor Migration and Glioblastoma Invasion

B Ortensi, D Osti, S Pellegatta, F Pisati, P Brescia, L Fornasari, D Levi, P Gaetani, P Colombo, A Ferri, S Nicolis, G Finocchiaro, Giuliana PELICCI

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The invasive nature of glioblastoma (GBM) is one important reason for treatment failure. GBM stem/progenitor cells retain the migratory ability of normal neural stem/progenitor cells and infiltrate the brain parenchyma. Here, we identify Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. Rai is expressed in neurogenic areas of the brain and its knockdown impairs progenitor migration to the olfactory bulb. Its expression is retained in GBM stem/progenitor cells where it exerts the same promigratory activity. Rai silencing in cancer stem/progenitor cells isolated from different patients causes significant decrease in cell migration and invasion, both in vitro and in vivo, providing survival benefit. Rai depletion is associated with alteration of multiple-signaling pathways, yet it always leads to reduced expression of proinvasive genes.

Lingua originale	Inglese
pagine (da-a)	817-832
Numero di pagine	16
Rivista	Stem Cells
Volume	30
Numero di pubblicazione	5
DOI	https://doi.org/10.1002/stem.1056
Stato di pubblicazione	Pubblicato - 2012

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10.1002/stem.1056

http://hdl.handle.net/11579/33761

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title = "Rai is a New Regulator of Neural Progenitor Migration and Glioblastoma Invasion",

abstract = "The invasive nature of glioblastoma (GBM) is one important reason for treatment failure. GBM stem/progenitor cells retain the migratory ability of normal neural stem/progenitor cells and infiltrate the brain parenchyma. Here, we identify Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. Rai is expressed in neurogenic areas of the brain and its knockdown impairs progenitor migration to the olfactory bulb. Its expression is retained in GBM stem/progenitor cells where it exerts the same promigratory activity. Rai silencing in cancer stem/progenitor cells isolated from different patients causes significant decrease in cell migration and invasion, both in vitro and in vivo, providing survival benefit. Rai depletion is associated with alteration of multiple-signaling pathways, yet it always leads to reduced expression of proinvasive genes.",

author = "B Ortensi and D Osti and S Pellegatta and F Pisati and P Brescia and L Fornasari and D Levi and P Gaetani and P Colombo and A Ferri and S Nicolis and G Finocchiaro and Giuliana PELICCI",

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doi = "10.1002/stem.1056",

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journal = "Stem Cells",

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T1 - Rai is a New Regulator of Neural Progenitor Migration and Glioblastoma Invasion

AU - Ortensi, B

AU - Osti, D

AU - Pellegatta, S

AU - Pisati, F

AU - Brescia, P

AU - Fornasari, L

AU - Levi, D

AU - Gaetani, P

AU - Colombo, P

AU - Ferri, A

AU - Nicolis, S

AU - Finocchiaro, G

AU - PELICCI, Giuliana

PY - 2012

Y1 - 2012

N2 - The invasive nature of glioblastoma (GBM) is one important reason for treatment failure. GBM stem/progenitor cells retain the migratory ability of normal neural stem/progenitor cells and infiltrate the brain parenchyma. Here, we identify Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. Rai is expressed in neurogenic areas of the brain and its knockdown impairs progenitor migration to the olfactory bulb. Its expression is retained in GBM stem/progenitor cells where it exerts the same promigratory activity. Rai silencing in cancer stem/progenitor cells isolated from different patients causes significant decrease in cell migration and invasion, both in vitro and in vivo, providing survival benefit. Rai depletion is associated with alteration of multiple-signaling pathways, yet it always leads to reduced expression of proinvasive genes.

AB - The invasive nature of glioblastoma (GBM) is one important reason for treatment failure. GBM stem/progenitor cells retain the migratory ability of normal neural stem/progenitor cells and infiltrate the brain parenchyma. Here, we identify Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. Rai is expressed in neurogenic areas of the brain and its knockdown impairs progenitor migration to the olfactory bulb. Its expression is retained in GBM stem/progenitor cells where it exerts the same promigratory activity. Rai silencing in cancer stem/progenitor cells isolated from different patients causes significant decrease in cell migration and invasion, both in vitro and in vivo, providing survival benefit. Rai depletion is associated with alteration of multiple-signaling pathways, yet it always leads to reduced expression of proinvasive genes.

UR - https://iris.uniupo.it/handle/11579/33761

U2 - 10.1002/stem.1056

DO - 10.1002/stem.1056

M3 - Article

SN - 1066-5099

VL - 30

SP - 817

EP - 832

JO - Stem Cells

JF - Stem Cells

IS - 5

ER -

Rai is a New Regulator of Neural Progenitor Migration and Glioblastoma Invasion

Abstract

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